Results 11 to 20 of about 145,462 (345)
Explainable AI for Retinoblastoma Diagnosis: Interpreting Deep Learning Models with LIME and SHAP
Diagnostics, 2023 Retinoblastoma is a rare and aggressive form of childhood eye cancer that requires prompt diagnosis and treatment to prevent vision loss and even death. Deep learning models have shown promising results in detecting retinoblastoma from fundus images, but
C. Chiesa-Estomba +5 more
semanticscholar +1 more source
BMJ Open Ophthalmology, 2021 Objective To explore living with heritable retinoblastoma, specifically survivors’ perceived role of regular follow-up at a retinoblastoma survivorship clinic.Methods and analysis Adult survivors of heritable retinoblastoma were recruited from the ...
Stina Lou +7 more
doaj +1 more source
Treatment of Retinoblastoma: What Is the Latest and What Is the Future
Frontiers in Oncology, 2022 The management of retinoblastoma, the most common intraocular malignancy in children, has changed drastically over the last decade. Landmark developments in local drug delivery, namely, safer techniques for intravitreal chemotherapy injection and ...
P. Schaiquevich +5 more
semanticscholar +1 more source
Nature Communications, 2021 Retinoblastoma is the most frequent intraocular malignancy in children, originating from a maturing cone precursor in the developing retina. Little is known on the molecular basis underlying the biological and clinical behavior of this cancer.
Jing Liu +59 more
semanticscholar +1 more source
Retinoblastoma from human stem cell-derived retinal organoids
Nature Communications, 2021 Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic inactivation of the RB1 gene. Children with germline mutations in RB1 have a high likelihood of developing retinoblastoma and other malignancies later in life ...
Jackie L. Norrie +18 more
semanticscholar +1 more source
Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma
Biosensors, 2021 Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches
R. Arshad +6 more
semanticscholar +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022 Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu +13 more
wiley +1 more source
Incidence and geographic distribution of retinoblastoma in Ethiopia
BMC Ophthalmology, 2023 Introduction Retinoblastoma is the most frequent intraocular malignancy of the eye in children, occurring in early childhood. Based on global estimates, Ethiopia is expected to observe over 200 new retinoblastoma cases per year, however without a cancer ...
Sadik Taju Sherief +7 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2006 Retinoblastoma is a rare eye tumor of childhood that arises in the retina. It is the most common intraocular malignancy of infancy and childhood; with an incidence of 1/15,000-20,000 live births. The two most frequent symptoms revealing retinoblastoma are leukocoria and strabismus.
Laurence Desjardins +5 more
openaire +4 more sources
Cell Death and Disease, 2021 Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing on 14,
Jie Yang +9 more
doaj +1 more source