Results 11 to 20 of about 151,276 (329)
CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]
BMC Cancer, 2019 Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Lena Andersch +15 more
semanticscholar +4 more sources
The management of retinoblastoma
Oncogene, 2018 Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but an uncommon paediatric cancer, with a constant incidence worldwide of 1:15,000-1:20,000 live births. Despite its rarity, Rb has served as a cornerstone in the field of oncology in many of the aspects that comprise cancer management, including classification schemes,
I. Fabian +15 more
semanticscholar +4 more sources
Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors [PDF]
Frontiers in Oncology, 2019 Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
S. Rajasekaran +12 more
semanticscholar +4 more sources
Update on pathology of retinoblastoma [PDF]
International Journal of Ophthalmology, 2018 Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
doaj +2 more sources
Asia-Pacific Journal of Oncology Nursing, 2017 From 7% to 10% of all retinoblastomas and from 44% to 71% of familial retinoblastomas in developed countries are diagnosed in the neonatal period, usually through pre- or post-natal screening prompted by a positive family history and sometimes ...
Tero T Kivelä, Theodora Hadjistilianou
doaj +6 more sources
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. [PDF]
Genes & Development, 1993 The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes potentially important for its growth-suppressing function. We have developed and used an improved version of the yeast two-hybrid system to isolate human cDNAs ...
T. Durfee +7 more
openalex +2 more sources
Mutation and Cancer: Statistical Study of Retinoblastoma
Proceedings of the National Academy of Sciences of the United States of America, 1971 Alfred G. Knudson
openalex +2 more sources
Explainable AI for Retinoblastoma Diagnosis: Interpreting Deep Learning Models with LIME and SHAP
Diagnostics, 2023 Retinoblastoma is a rare and aggressive form of childhood eye cancer that requires prompt diagnosis and treatment to prevent vision loss and even death. Deep learning models have shown promising results in detecting retinoblastoma from fundus images, but
C. Chiesa-Estomba +5 more
semanticscholar +1 more source
Nature Reviews Disease Primers, 2015 Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000 children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are mutated in a susceptible retinal cell, probably a cone photoreceptor precursor.
Dimaras, Helen +10 more
+9 more sources
Revista chilena de pediatría, 1979 Retinoblastoma is a radiosensitive malignancy of neuroblastic origin that primarily affects young children. Its relatively low incidence belies its potential importance in the understanding of tumor biology in general. A case is made for referral of all retinoblastoma patients to centers with retinoblastoma protocols.
Marchevsky, Silvia +4 more
openaire +5 more sources