Results 151 to 160 of about 357,868 (360)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Induction of transforming growth factor-beta 1 (TGF-beta 1), receptor expression and TGF-beta 1 protein production in retinoic acid-treated HL-60 cells: possible TGF-beta 1-mediated autocrine inhibition [PDF]

, 1991
LA Falk, Fabrizio De Benedetti, N Lohrey, MC Birchenall-Roberts, LW Ellingsworth, CR Faltynek, FW Ruscetti   +6 more
openalex   +1 more source

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. [PDF]

ACS Med Chem Lett, 2023
Schnute ME, Trujillo JI, Lee KL, Unwalla R, Vajdos FF, Kauppi B, Nuhant P, Flick AC, Crouse KK, Zhao Y, Samuel A, Lombardo V, Taylor AP, Brault AL, Knafels JD, Vazquez ML, Berstein G.   +16 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing.

, 1994
Anders Åström, U. Pettersson, Pascal Chambon, John J. Voorhees   +3 more
openalex   +1 more source

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression. [PDF]

NPJ Precis Oncol, 2023
Lavudi K, Banerjee A, Li N, Yang Y, Cai S, Bai X, Zhang X, Li A, Wani E, Yang SM, Zhang J, Rai G, Backes F, Patnaik S, Guo P, Wang QE.   +15 more
europepmc   +1 more source

The Role of Interleukin‐23 and Interleukin‐17 in Peri‐Implant Crevicular Fluid of Subjects With Peri‐Implant Disease: A Systematic Review

Journal of Clinical Laboratory Analysis, EarlyView.
The role of IL‐23/IL‐17 cytokine axis in peri‐implant disease. ABSTRACT Background Activation of the IL‐23/IL‐17 cytokine axis could trigger peri‐implant bone loss. The aim of this review was to analyze whether in people with peri‐implantitis (PI) and peri‐implant mucositis (PM) the concentrations of the interleukin‐23 and interleukin‐17 in peri ...
Mario Alberto Alarcón‐Sánchez, Julieta Sarai Becerra‐Ruiz, Ruth Rodríguez‐Montaño, Sarah Monserrat Lomelí‐Martínez, Lilibeth‐Stephania Escoto‐Vasquez, Artak Heboyan   +5 more
wiley   +1 more source

Pharmacologic Repression of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen‐Induced Arthritis Experimental Model

Arthritis & Rheumatology, 2014
M. Chang, B. Lyda, T. Kamenecka, P. Griffin   +3 more
semanticscholar   +1 more source

Female Starlings With Experimentally Impaired Pre‐Laying Condition Produce Smaller But Vitamin A Richer Eggs

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
We experimentally impaired the pre‐laying condition of female starlings by clipping two flight feathers per wing at the beginning of the breeding season, before egg laying. Impaired females laid the same number of eggs as control females, but smaller, and with higher levels of yolk vitamin A.
S. Casquero, I. Redondo, E. Gómez‐Llanos, A. Á. Romero‐Haro, D. Gil, L. Pérez‐Rodríguez   +5 more
wiley   +1 more source

Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling

npj Breast Cancer
Point mutations in the ligand binding domain of retinoic acid receptor alpha (RARα) are linked to breast fibroepithelial tumor development, but their role in solid tumorigenesis is unclear.
Xi Xiao Huang, Ley Moy Ng, Po-Hsien Lee, Peiyong Guan, Mun Juinn Chow, Aisyah Binte Mohamed Bashir, Meina Lau, Kenric Yi Shu Tan, Zhimei Li, Jason Yongsheng Chan, Jing Han Hong, Sheng Rong Ng, Tun Kiat Ko, Hong Lee Heng, Hsiang Ling Teo, Daniela Rhodes, Patrick Tan, Puay Hoon Tan, Donald P. McDonnell, Bin Tean Teh   +19 more
doaj   +1 more source