Results 141 to 150 of about 86,354 (308)

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

The mediating mechanism of Oct4 in the process of cleft palate induced by 2, 3, 7, 8-tetrachlorodibenz-p-dioxin (TCDD) and all-trans retinoic acid

Ecotoxicology and Environmental Safety
2, 3, 7, 8-tetrachlorodiphenyl-p-dioxin (TCDD) and all-trans retinoic acid (atRA) have been shown to be inducers of cleft palate (CP). Relevant studies have shown that Oct transcription factor 4 (Oct4) can regulate the expression of the aromatic ...
Zengli Yu, Yaxin Zhang, Shiyi Wu, Ziyan Sun, Zhan Gao, Yao Chen, Xiangdong Wang, Dongliang Xu, Xiaozhuan Liu   +8 more
doaj   +1 more source

The role of retinoic acid receptor-related orphan receptors in skeletal diseases. [PDF]

Front Endocrinol (Lausanne), 2023
Zhang Y, Ma J, Bao X, Hu M, Wei X.
europepmc   +1 more source

Meet the Editorial Team. An interview with Angelo Iulianella, Assistant Editor, Dalhousie University Faculty of Medicine, Canada

Developmental Dynamics, EarlyView.
Paul Trevorrow, Angelo Iulianella
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Binding of Retinoic Acid Receptor Heterodimers to DNA

, 1998
International audienceThe retinoic acid signaling pathway is controlled essentially through two types of nuclear receptors, RARs and RXRs. Ligand dependent activation or repression of retinoid-regulated genes is dependent on the binding of retinoic acid ...
Formstecher, Pierre, Lefebvre, Philippe, Mouchon, Arnaud, Lefebvre, Bruno   +3 more
core   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source

Differentiation Syndrome and Sweet Syndrome‐Like Overlap Following Venetoclax–Azacytidine and G‐CSF Therapy

JEADV Clinical Practice, EarlyView.
ABSTRACT Differentiation syndrome (DS) and Sweet syndrome (SS) are inflammatory complications mediated by cytokine dysregulation, classically associated with therapies that promote myeloid differentiation or cytokine release. While DS has been primarily linked to all‐trans retinoic acid (ATRA) and IDH inhibitors, recent evidence suggests that ...
Katerina Grafanaki, Maria Gerbesi, Zoe Apalla, Dimitrios Tsokanas, Efstathia Pasmatzi, Alexandros Spyridonidis, Maria Liga   +6 more
wiley   +1 more source

Retinoic Acid Receptor Is a Novel Therapeutic Target for Postoperative Cognitive Dysfunction. [PDF]

Pharmaceutics, 2023
Bao Y, Rong W, Zhu A, Chen Y, Chen H, Hong Y, Le J, Wang Q, Naman CB, Xu Z, Liu L, Cui W, Wu X.   +12 more
europepmc   +1 more source

EXPRESSION OF A DOMINANT-NEGATIVE RETINOIC ACID RECEPTOR-GAMMA IN XENOPUS EMBRYOS LEADS TO PARTIAL RESISTANCE TO RETINOIC ACID

The administration of the teratogen retinoic acid (and other retinoids) to vertebrate embryos causes a range of developmental abnormalities. It remains to be shown how these teratogenic effects are mediated, and whether or not they reflect any ...

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