Results 121 to 130 of about 86,354 (308)

The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited

Nature Communications, 2017
The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF ...
Qing Xu, Siriporn Jitkaew, Swati Choksi, Chamila Kadigamuwa, Jianhui Qu, Moran Choe, Jonathan Jang, Chengyu Liu, Zheng-gang Liu   +8 more
doaj   +1 more source

Thyroid hormone receptor can modulate retinoic acid-mediated axis formation in frog embryogenesis.

, 1993
Thyroid hormone receptor acts as a hormone-dependent transcriptional transactivator and as a transcriptional repressor in the absence of thyroid hormone.
Eisenman, R N, Banker, D E
core  

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth

, 1997
We have previously reported an unexpected relationship between retinoic acid-induced inhibition of cell growth and the ability of various cell lines to metabolize the retinoid.
G. Scita, M. Haque, M. Isogai, L. M. De Luca, M. V. Chiantore   +4 more
core  

Regulation of Epidermal Growth Factor Receptor Synthesis by Retinoic Acid and Dexamethasone [PDF]

, 1989
Fetal rat lung (FRL) cells incubated in the presence of retinoic acid or dexamethasone exhibit altered 125I-epidermal growth factor (EOF) binding capacity. Retinoic acid enhances 125I-EGF binding 3-fold following 24 hours of 37° incubation.
Oberg, Kerby C.
core  

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription [PDF]

, 1990
SummaryWe have developed an assay where the potency of retinoids in retinoic acid receptor (RAR) mediated transcriptional activation can be rapidly evaluated.
Astrom, Anders, Voorhees, John J., Pettersson, Ulrika, Krust, Andree, Chambon, Pierre   +4 more
core  

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

The role of RARG in solid tumor progression and therapeutic potential

Discover Oncology
Retinoic acid receptor gamma (RARG), a crucial member of the retinoic acid receptors (RARs) family, encompasses two distinct isoforms, namely RARγ1 and RARγ2. RARG is organized into five functional domains: A/B, C, D, E and F.
Shuyan Guo, Haobo Han, Biao Ding, Wentao Zhang, Long Qin   +4 more
doaj   +1 more source

Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats

Frontiers in Neuroscience
Increasing evidence suggests that all-trans retinoic acid (ATRA) contributes to the pathogenesis of depression. Although numerous studies have emphasized the role of hippocampal glutamatergic transmission and dendritic spine abnormalities in ATRA-induced
Yuan-Zhong Kai, Chun Xia, Qing-Hong Shan, Zheng-Quan Tang   +3 more
doaj   +1 more source