Results 111 to 120 of about 3,704,275 (297)

Pharmacological inhibition of frizzled 4 delays cell cycle progression and limits oral squamous cell carcinoma growth

Frontiers in Cell and Developmental Biology
Oral squamous cell carcinoma is an aggressive malignancy driven by aberrant signaling pathways, with Wnt signaling acting as a central regulator of proliferation, tumor-microenvironment interactions, and oncogenic growth.
Riccardo Destefani, Ilaria J. Valookkaran, Sabrina Bensland, Christian T. Meisel, Cristina Porcheri   +4 more
doaj   +1 more source

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer

, 2013
About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based
Linderholm, Barbro K., Kovacs, Aniko,, Hultin-Rosenberg, Lina,, Lehtio, Janne, Helou, Khalil,, Krawiec, Kamilla, Stål, Olle,, Hultin-Rosenberg, Lina, Forshed, Jenny, Krawiec, Kamilla,, Forshed, Jenny,, Stål, Olle, Sanchez, Betzabe C.,, Lehtio, Janne,, Hjerpe, Anders, Sanchez, Betzabe C, Kovacs, Aniko, Sanchez, Betzabe C., Mundt, Filip, Linderholm, Barbro,, Martens, Ulf,, Mathe, Gyongyver,, Hjerpe, Anders,, Linderholm, Barbro K.,, Mathe, Gyongyver, Martens, Ulf, Johansson, Henrik J, Panizza, Elena,, Yakhini, Zohar, Johansson, Henrik J., Yakhini, Zohar,, Kanter, Lena,, Kanter, Lena, Johansson, Henrik J.,, Lundgren, Bo,, Panizza, Elena, Lundgren, Bo, Helou, Khalil, Mundt, Filip,   +38 more
core   +1 more source

RARRES1 (retinoic acid receptor responder (tazarotene induced) 1) [PDF]

, 2007
Review on RARRES1 (retinoic acid receptor responder (tazarotene induced) 1), with data on DNA, on the protein encoded, and where the gene is ...
Lo, KW, Chung, GTY
core   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects [PDF]

, 2008
A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology.
Bajor, Antal
core   +1 more source

RARRES3 (retinoic acid receptor responder (tazarotene induced) 3) [PDF]

, 2012
Review on RARRES3 (retinoic acid receptor responder (tazarotene induced) 3), with data on DNA, on the protein encoded, and where the gene is ...
Scharadin, T, Eckert, RL
core   +1 more source

Retinobenzoic Acids and Nuclear Retinoic Acid Receptors.

Cell Structure and Function, 1991
Retinoids (retinoic acid and its analogs) are widely involved in the control of cell proliferation, cell differentiation and embryonic development. A series of potent and novel synthetic retinoids named retinobenzoic acids has been developed. Retinobenzoic acids have proven to be useful tools in the investigation of the molecular mechanisms of ...
openaire   +3 more sources

The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited

Nature Communications, 2017
The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF ...
Qing Xu, Siriporn Jitkaew, Swati Choksi, Chamila Kadigamuwa, Jianhui Qu, Moran Choe, Jonathan Jang, Chengyu Liu, Zheng-gang Liu   +8 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source