Results 91 to 100 of about 86,354 (308)

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer

, 2013
About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based
Linderholm, Barbro K., Kovacs, Aniko,, Hultin-Rosenberg, Lina,, Lehtio, Janne, Helou, Khalil,, Krawiec, Kamilla, Stål, Olle,, Hultin-Rosenberg, Lina, Forshed, Jenny, Krawiec, Kamilla,, Forshed, Jenny,, Stål, Olle, Sanchez, Betzabe C.,, Lehtio, Janne,, Hjerpe, Anders, Sanchez, Betzabe C, Kovacs, Aniko, Sanchez, Betzabe C., Mundt, Filip, Linderholm, Barbro,, Martens, Ulf,, Mathe, Gyongyver,, Hjerpe, Anders,, Linderholm, Barbro K.,, Mathe, Gyongyver, Martens, Ulf, Johansson, Henrik J, Panizza, Elena,, Yakhini, Zohar, Johansson, Henrik J., Yakhini, Zohar,, Kanter, Lena,, Kanter, Lena, Johansson, Henrik J.,, Lundgren, Bo,, Panizza, Elena, Lundgren, Bo, Helou, Khalil, Mundt, Filip,   +38 more
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Partial hearing recovery after cochlear nerve surface transplantation of hair follicle‐derived neural crest stem cells in neural hearing loss rat

Animal Models and Experimental Medicine, EarlyView.
This study comprises three experimental parts. Part 1. Time‐course of ouabain‐induced hearing loss. Rats received ouabain (10 mM) via round window application. ABR/DPOAE tests and histological analyses were performed at 2, 7, and 30 days post‐treatment to characterize SGN and glial cell degeneration. Part 2.
Huidong Chen, Yunlong Zhang, Huanzhi Wan, Bingqian Yang, Tianyi Liu, Jie Wang, Hua Liao, Yuanyuan Zhang, Zhijian Zhang, Qingquan Hua   +9 more
wiley   +1 more source

Retinoic acid triazole promotes neurotrophin-mediated cell growth and proliferation in nerve cells

Bangladesh Journal of Pharmacology, 2014
In the present study, fluorophenyl retinoic acid triazole, a retinoic acid derivative having more bioavailability compared to the parent retinoic acid was investigated against cell growth and proliferation.
Hui Shi, Yan Xiao Long, Yi Zhang, Ming Zhong, Kuang Zheng   +4 more
doaj  

Alitretinoin in treatment of chronic hand eczema – mechanism of action

Przegląd Dermatologiczny, 2016
Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results,
Maria Matejko, Beata Kręcisz
doaj   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt

Neural Regeneration Research, 2018
Some adult vertebrate species, such as newts, axolotls and zebrafish, have the ability to regenerate their central nervous system (CNS). However, the factors that establish a permissive CNS environment for correct morphological and functional ...
Sarah E Walker, Rachel Nottrodt, Lucas Maddalena, Christopher Carter, Gaynor E Spencer, Robert L Carlone   +5 more
doaj   +1 more source

Interaction between cellular retinoic acid-binding protein II and histone hypoacetylation in renal cell carcinoma

, 2008
Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation which is controlled by histone deacetylase (HD), the study
Viroj Wiwanitkit, Wiwanitkit, Viroj
core  

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells [PDF]

, 2013
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined.
Wei, Yijuan, Hu, Bingfang, Wen Xie, Xie Wen, Zhai Yonggong, Yonggong Zhai, Huang Min, Bingfang Hu, Hu, B, Xie, W, Jun Zhang, Yijuan Wei, Zhai, Yonggong, Xie, Wen, Min Huang, Zhang Jun, Hu Bingfang, Huang, M, Huang, Min, Wei Yijuan, Zhang, Jun, Zhang, J, Wei, Y, Zhai, Y   +23 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source