Results 191 to 200 of about 146,563 (345)

A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment. [PDF]

Sci Rep, 2023
Wei CH, Huang L, Kreh B, Liu X, Tyutyunyk-Massey L, Kawakami M, Chen Z, Shi M, Kozlov S, Chan KC, Andresson T, Carrington M, Vuligonda V, Sanders ME, Horowitz A, Hwu P, Peng W, Dmitrovsky E, Liu X.   +18 more
europepmc   +1 more source

Inhibition of Retinoic Acid Receptor Gamma Improves Bovine Embryo Development. [PDF]

Vet Sci
Wang X, Wan W, Su Y, Xie S, Jiang F, Yang Z, Xiehe S, Ma W, Yue L, Li N, Wang A, Guo J, Li X, Liu X, Tang Y.   +14 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

From Discovery to Clinical Trial: YCT-529, an Oral NonHormonal Male Contraceptive Targeting the Retinoic Acid Receptor Alpha. [PDF]

J Med Chem
Shi R, Al Noman MA, Mannowetz N, Cheryala N, Haque E, Maitra S, Naqvi T, Chung SSW, Bakshi A, Hawkinson JE, Wong HL, Wolgemuth DJ, Georg GI.   +12 more
europepmc   +1 more source

Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction. [PDF]

Front Immunol, 2023
Zhao JY, Yuan XK, Luo RZ, Wang LX, Gu W, Yamane D, Feng H.   +6 more
europepmc   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis. [PDF]

Proc Natl Acad Sci U S A
Chakraborty S, Wang S, Ruhala J, Mehling B, Liu J, Waldhaus J.   +5 more
europepmc   +1 more source

Segmented filamentous bacteria impede rotavirus infection via retinoic acid receptor-mediated signaling. [PDF]

Gut Microbes, 2023
Ngo VL, Shi Z, Jiang B, Gewirtz AT.
europepmc   +1 more source

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers

, 1992
B. M. Forman
openalex   +1 more source

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, EarlyView.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source