Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
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Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials
Experimental Physiology, EarlyView.Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler +2 more
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Retinoic acid receptor-β deletion in a model of early pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. [PDF]
Am J Cancer ResMere Del Aguila E, Tang XH, Gudas LJ.
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Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing
The Journal of Physiology, EarlyView.Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda +5 more
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The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
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Development of the retinoic acid receptor alpha-specific antagonist YCT-529 for male contraception: A brief review. [PDF]
ContraceptionShi R, Wolgemuth DJ, Georg GI.
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The Journal of Physiology, EarlyView.Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires +15 more
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Abundance of single filamentous bacteria, and expression of differentiated Th17 cells, their signature cytokine IL-17 A, and retinoic acid receptor are predictive of poor rotavirus vaccine take. [PDF]
Virol JBubuluma R, Seheri M, Magwira CA.
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Computational and Systems Oncology, Volume 6, Issue 1, December 2026.Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
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Retinoic acid receptor responder 2 and lipid metabolic reprogramming: A new insight into brain metastasis. [PDF]
Cancer InnovWang L, Gao Y.
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