Results 221 to 230 of about 79,879 (264)
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Retinoic acid receptors at 35 years
Journal of Molecular Endocrinology, 2022For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action. This review is about the discovery of specific receptors for the vitamin A derivative, retinoic acid (RA), which launched extensive molecular,
Martin Petkovich, Pierre Chambon
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1992
Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System
Annual Review of Immunology, 2016Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity.
Alexandre, Larange, Hilde, Cheroutre
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Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors
The International Journal of Developmental Biology, 1995An excess of retinoic acid (RA) in the mouse embryo in utero produces hypochondrogenesis and severe limb bone deformities. Since one of the RA receptors--RAR-beta 2, is specifically induced in the limb bud cells upon treatment of embryos with teratogenic doses of RA, we investigated if this receptor played a role in teratogenesis by regulating the ...
H, Jiang +6 more
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Retinoids, Retinoic Acid Receptors, and Cancer
Annual Review of Pathology: Mechanisms of Disease, 2011Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids. Retinoid signaling is often compromised early in carcinogenesis, which suggests that a reduction in retinoid signaling may ...
Xiao-Han, Tang, Lorraine J, Gudas
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1995
Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Identification of a receptor for the morphogen retinoic acid
Nature, 1987Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
V, Giguere +3 more
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2015
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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2010
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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Developmental roles of the retinoic acid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1995Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced ...
Lohnes, David +8 more
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