Results 191 to 200 of about 3,704,275 (297)

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source

From Discovery to Clinical Trial: YCT-529, an Oral NonHormonal Male Contraceptive Targeting the Retinoic Acid Receptor Alpha. [PDF]

J Med Chem
Shi R, Al Noman MA, Mannowetz N, Cheryala N, Haque E, Maitra S, Naqvi T, Chung SSW, Bakshi A, Hawkinson JE, Wong HL, Wolgemuth DJ, Georg GI.   +12 more
europepmc   +1 more source

A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment. [PDF]

Sci Rep, 2023
Wei CH, Huang L, Kreh B, Liu X, Tyutyunyk-Massey L, Kawakami M, Chen Z, Shi M, Kozlov S, Chan KC, Andresson T, Carrington M, Vuligonda V, Sanders ME, Horowitz A, Hwu P, Peng W, Dmitrovsky E, Liu X.   +18 more
europepmc   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8⁺ T cells. [PDF]

Front Immunol
Cai Z, Kozai M, Mita H, Takeuchi H, Mizuno S, Matsuo K, Takada K.   +6 more
europepmc   +1 more source

Investigation of selective retinoic acid receptor alpha antagonist ER-50891 and related analogs for male contraception. [PDF]

Arch Pharm (Weinheim), 2023
Kyzer JL, Noman MAA, Cuellar RAD, Chung SSW, Maitra S, Naqvi T, Hawkinson JE, Wolgemuth DJ, Georg GI.   +8 more
europepmc   +1 more source

AQP1 Corrects Acinar Cells’ Secretion Deficits in Sjögren's Disease

Oral Diseases, EarlyView.
ABSTRACT Introduction Sjögren's disease (SjD) is a systemic autoimmune disease characterized by dry mouth, dry eyes, and profound fatigue. Preclinical studies suggest that AQP1 gene expression in salivary glands corrects salivary hypofunction in preclinical and clinical studies of radiation‐induced xerostomia and improves salivary and lacrimal function
Paola Perez, Blake M. Warner, Youngmi Ji, Sandra Afione, Thomas J. F. Pranzatelli, Margaret E. Beach, Zohreh Khavandgar, Margie Grisius, Eileen Pelayo, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core, Alan N. Baer, John A. Chiorini   +12 more
wiley   +1 more source

Redefining retinoic acid receptor expression in zebrafish embryos using Hybridization Chain Reaction. [PDF]

Differentiation
Gray R, Lovely CB.
europepmc   +1 more source

Retinoic Acid Receptor Responder Protein 1 Promotes Tubular Fibrosis via the KH RNA Binding Domain Containing, Signal Transduction Associated 1/Steroid Receptor Coactivator/p-Signal Transducer and Activator of Transcription 3 Axis. [PDF]

J Am Soc Nephrol
Ye L, Jiang Z, Wu Y, Zeng Y, Chen X, Feng B, Yin L, Gao Y, Xu W, Yan S, Li Y, Wu J, Li Q, Chen A.   +13 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source