Results 21 to 30 of about 146,563 (345)

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

Discover Oncology, 2023
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong, Xiaojun Liu, Weihua Ding, Lizhong Peng, Xuhui Zeng, Yayun Gu   +5 more
doaj   +1 more source

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization

Frontiers in Immunology, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Kunihiro Otsuka, Shin-ichi Tsukumo, Shin-ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +11 more
doaj   +1 more source

Antagonism between retinoic acid receptors. [PDF]

Molecular and Cellular Biology, 1991
In the developing mouse, retinoic acid receptors (RARs) beta and gamma 1 are expressed in characteristic spatiotemporal patterns which are correlated with different developmental fates of the respective tissues. Understanding the cues that regulate the expression of the various RARs may therefore provide insights into the process of tissue ...
M, Husmann, J, Lehmann, B, Hoffmann, T, Hermann, M, Tzukerman, M, Pfahl   +5 more
openaire   +2 more sources

Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis. [PDF]

Proc Natl Acad Sci U S A
DiKun KM, Tang XH, Fu L, Choi ME, Lu C, Gudas LJ.   +5 more
europepmc   +3 more sources

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Maternal smoking and the retinoid pathway in the developing lung

Respiratory Research, 2012
Background Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring.
Manoli Sara E, Smith Lacey A, Vyhlidal Carrie A, An Chang, Porrata Yolanda, Cardoso Wellington V, Baron Rebecca M, Haley Kathleen J   +7 more
doaj   +1 more source

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
core   +2 more sources

Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis

Toxins, 2021
Retinoic acid (RA) is one of the factors crucial for cell growth, differentiation, and embryogenesis; it interacts with the retinoic acid receptor and retinoic acid X receptor to eventually regulate target gene expression in chordates.
Kichul Cho, Sang-Moo Lee, Jina Heo, Yong Min Kwon, Dawoon Chung, Woon-Jong Yu, Seung Seob Bae, Grace Choi, Dae-Sung Lee, Youngjun Kim   +9 more
doaj   +1 more source

A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment [PDF]

, 1995
We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17. This translocation could be considered a variant of the APL-specific t(15;17).
Bengoechea, E. (Enrique), Calasanz-Abinzano, M.J. (Maria Jose), Cigudosa, J.C. (Juan Cruz), Gullon, A. (Arturo), Marin, J. (Julián), Odero, M.D. (Maria Dolores)   +5 more
core   +1 more source

Retinoic acid synthesis and functions in early embryonic development

Cell & Bioscience, 2012
Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles in cell growth, differentiation, and organogenesis. The production of RA from retinol requires two consecutive enzymatic reactions catalyzed by different sets ...
Kam Richard Kin Ting, Deng Yi, Chen Yonglong, Zhao Hui   +3 more
doaj   +1 more source