Results 21 to 30 of about 357,868 (360)

A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling.

Journal of the American Society of Nephrology, 2017
Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of CKD in the first three decades of life. However, for most patients with CAKUT, the causative mutation remains unknown.
A. Vivante, Nina Mann, H. Yonath, Anna-Carina Weiss, Maike Getwan, Michael M. Kaminski, Tobias Bohnenpoll, C. Teyssier, J. Chen, S. Shril, A. T. van der Ven, Hadas Ityel, J. Schmidt, E. Widmeier, S. Bauer, S. Sanna-Cherchi, A. Gharavi, Weining Lu, D. Magen, R. Shukrun, R. Lifton, V. Tasic, H. Stanescu, V. Cavaillès, R. Kleta, Y. Anikster, B. Dekel, A. Kispert, S. Lienkamp, F. Hildebrandt   +29 more
semanticscholar   +1 more source

Retinoic acid synthesis and functions in early embryonic development

Cell & Bioscience, 2012
Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles in cell growth, differentiation, and organogenesis. The production of RA from retinol requires two consecutive enzymatic reactions catalyzed by different sets ...
Kam Richard Kin Ting, Deng Yi, Chen Yonglong, Zhao Hui   +3 more
doaj   +1 more source

RARG Gene Dysregulation in Acute Myeloid Leukemia

Frontiers in Molecular Biosciences, 2019
Retinoic acid receptor γ (RARγ) belongs to the nuclear receptor superfamily and shares 90% homology with retinoic acid receptor α (RARα) and retinoic acid receptor β (RARβ).
Maria Rosa Conserva, Immacolata Redavid, Luisa Anelli, Antonella Zagaria, Giorgina Specchia, Francesco Albano   +5 more
doaj   +1 more source

Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis

Toxins, 2021
Retinoic acid (RA) is one of the factors crucial for cell growth, differentiation, and embryogenesis; it interacts with the retinoic acid receptor and retinoic acid X receptor to eventually regulate target gene expression in chordates.
Kichul Cho, Sang-Moo Lee, Jina Heo, Yong Min Kwon, Dawoon Chung, Woon-Jong Yu, Seung Seob Bae, Grace Choi, Dae-Sung Lee, Youngjun Kim   +9 more
doaj   +1 more source

Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. [PDF]

PLoS ONE, 2007
Retinoic acid (RA), the bioactive derivative of Vitamin A, by epigenetically controlling transcription through the RA-receptors (RARs), exerts a potent antiproliferative effect on human cells.
Giulia Somenzi, Giusy Sala, Stefano Rossetti, MingQiang Ren, Riccardo Ghidoni, Nicoletta Sacchi   +5 more
doaj   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Molecular Characterization of Retinoic Acid Receptor CgRAR in Pacific Oyster (Crassostrea gigas)

Frontiers in Physiology, 2021
Retinoic acid (RA) signaling pathways mediated by RA receptors (RARs) are essential for many physiological processes such as organ development, regeneration, and differentiation in animals.
Kaidi Jin, Qianqian Jin, Zhongqiang Cai, Baoyu Huang, Lei Wei, Meiwei Zhang, Wen Guo, Yaqiong Liu, Xiaotong Wang   +8 more
doaj   +1 more source

The negative side of retinoic acid receptors [PDF]

Neurotoxicology and Teratology, 2011
This is a review of research that supports a hypothesis regarding early restriction of gene expression in the vertebrate embryo. We hypothesize that vertebrate retinoic acid receptors (RARs for several vertebrates but rars for zebrafish) are part of an embryonic, epigenetic switch whose default position, at the time of fertilization is "OFF".
Laura Mackey, Betsy Dobbs-McAuliffe, Susan Donerly, Elwood Linney   +3 more
openaire   +3 more sources

Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut. [PDF]

PLoS ONE, 2013
Vagal neural crest cells (VNCCs) arise in the hindbrain, and at (avian) embryonic day (E) 1.5 commence migration through paraxial tissues to reach the foregut as chains of cells 1-2 days later.
Johanna E Simkin, Dongcheng Zhang, Benjamin N Rollo, Donald F Newgreen   +3 more
doaj   +1 more source

Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation

Cell Death and Disease, 2022
In adult skeletal muscle, satellite cells are in a quiescent state, which is essential for the future activation of muscle homeostasis and regeneration.
Wenzhe Luo, Yueyuan Xu, Ruige Liu, Yinlong Liao, Sheng Wang, Haoyuan Zhang, Xinyun Li, Heng Wang   +7 more
doaj   +1 more source