Results 31 to 40 of about 357,868 (360)
Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers
Frontiers in Cell and Developmental Biology, 2023 Retinoic acid (RA) is a vital metabolite derived from vitamin A. RA plays a prominent role during development, which helps in embryological advancement and cellular differentiation.
Kousalya Lavudi +7 more
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Activation of Retinoic Acid Receptors by Dihydroretinoids [PDF]
Molecular Pharmacology, 2009 Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number of genes. Stereospecific saturation of the C(13)-C(14) double bond of all-trans-retinol by the enzyme, retinol saturase (RetSat), leads to the production of (R)-all-trans-13,14-dihydroretinol.
Johannes von Lintig +8 more
openaire +3 more sources
Haematologica, 2019 Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu +9 more
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The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes [PDF]
, 2014 Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation.
Alison M. Urvalek +2 more
openaire +3 more sources
Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer
Nature Communications, 2013 About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based
H. Johansson +17 more
semanticscholar +1 more source
Nature Communications, 2016 Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homeostasis of the tumour microenvironment. Here the authors show that all-trans retinoic acid reduces retinoic acid receptor beta dependent-actomyosin contractility ...
Antonios Chronopoulos +10 more
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Hematology, 2023 In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL).
Danyang Wu, Ran Gao
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European Journal of Neuroscience, 2013 The retinoic acid receptor (RAR) α system plays a key role in the adult brain, participating in the homeostatic control of synaptic plasticity, essential for memory function. Here we show that RARα signalling is down‐regulated by amyloid beta (Aβ), which
Maria B. Goncalves +6 more
semanticscholar +1 more source
The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
Nature Communications, 2017 Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and ...
Vikas Chandra +5 more
doaj +1 more source
Biology and Life Sciences Forum, 2023 The biological activity of retinoic acid or all-trans retinoic acid (ATRA) is mediated by retinoic receptors, which are ligand-dependent transcription factors that activate genes crucial for cell differentiation.
John Charles Rotondo +11 more
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