Results 21 to 30 of about 3,704,275 (297)

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization

Frontiers in Immunology, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Kunihiro Otsuka, Shin-ichi Tsukumo, Shin-ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +11 more
doaj   +1 more source

A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development [PDF]

, 2010
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived ...
Dabouras, Vasilios, Marino, Daniela, Vasilios Dabouras, Detmar, Michael, Braendli, Andre W., Michael Detmar, André W. Brändli, Daniela Marino   +7 more
core   +1 more source

Maternal smoking and the retinoid pathway in the developing lung

Respiratory Research, 2012
Background Maternal smoking is a risk factor for pediatric lung disease, including asthma. Animal models suggest that maternal smoking causes defective alveolarization in the offspring.
Manoli Sara E, Smith Lacey A, Vyhlidal Carrie A, An Chang, Porrata Yolanda, Cardoso Wellington V, Baron Rebecca M, Haley Kathleen J   +7 more
doaj   +1 more source

Retinoic acid synthesis and functions in early embryonic development

Cell & Bioscience, 2012
Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles in cell growth, differentiation, and organogenesis. The production of RA from retinol requires two consecutive enzymatic reactions catalyzed by different sets ...
Kam Richard Kin Ting, Deng Yi, Chen Yonglong, Zhao Hui   +3 more
doaj   +1 more source

RARG Gene Dysregulation in Acute Myeloid Leukemia

Frontiers in Molecular Biosciences, 2019
Retinoic acid receptor γ (RARγ) belongs to the nuclear receptor superfamily and shares 90% homology with retinoic acid receptor α (RARα) and retinoic acid receptor β (RARβ).
Maria Rosa Conserva, Immacolata Redavid, Luisa Anelli, Antonella Zagaria, Giorgina Specchia, Francesco Albano   +5 more
doaj   +1 more source

Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis

Toxins, 2021
Retinoic acid (RA) is one of the factors crucial for cell growth, differentiation, and embryogenesis; it interacts with the retinoic acid receptor and retinoic acid X receptor to eventually regulate target gene expression in chordates.
Kichul Cho, Sang-Moo Lee, Jina Heo, Yong Min Kwon, Dawoon Chung, Woon-Jong Yu, Seung Seob Bae, Grace Choi, Dae-Sung Lee, Youngjun Kim   +9 more
doaj   +1 more source

Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. [PDF]

PLoS ONE, 2007
Retinoic acid (RA), the bioactive derivative of Vitamin A, by epigenetically controlling transcription through the RA-receptors (RARs), exerts a potent antiproliferative effect on human cells.
Giulia Somenzi, Giusy Sala, Stefano Rossetti, MingQiang Ren, Riccardo Ghidoni, Nicoletta Sacchi   +5 more
doaj   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Pathogenesis of retinoic acid-induced spina bifida in rat embryos [PDF]

, 2008
In a previous study, we showed that the intrauterine exposure of rat embryos to retinoic acid (RA) in the organogenesis period (8-11 days of gestation) induced various malformations according to the dose and timing of RA administration.
コニシ, ヒロヨシ, 小西, 啓悦, 1430, Konishi, Hiroyoshi   +3 more
core   +1 more source