Results 21 to 30 of about 86,354 (308)

Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis

Toxins, 2021
Retinoic acid (RA) is one of the factors crucial for cell growth, differentiation, and embryogenesis; it interacts with the retinoic acid receptor and retinoic acid X receptor to eventually regulate target gene expression in chordates.
Kichul Cho, Sang-Moo Lee, Jina Heo, Yong Min Kwon, Dawoon Chung, Woon-Jong Yu, Seung Seob Bae, Grace Choi, Dae-Sung Lee, Youngjun Kim   +9 more
doaj   +1 more source

Retinoic acid synthesis and functions in early embryonic development

Cell & Bioscience, 2012
Retinoic acid (RA) is a morphogen derived from retinol (vitamin A) that plays important roles in cell growth, differentiation, and organogenesis. The production of RA from retinol requires two consecutive enzymatic reactions catalyzed by different sets ...
Kam Richard Kin Ting, Deng Yi, Chen Yonglong, Zhao Hui   +3 more
doaj   +1 more source

RARG Gene Dysregulation in Acute Myeloid Leukemia

Frontiers in Molecular Biosciences, 2019
Retinoic acid receptor γ (RARγ) belongs to the nuclear receptor superfamily and shares 90% homology with retinoic acid receptor α (RARα) and retinoic acid receptor β (RARβ).
Maria Rosa Conserva, Immacolata Redavid, Luisa Anelli, Antonella Zagaria, Giorgina Specchia, Francesco Albano   +5 more
doaj   +1 more source

Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation

Cell Death and Disease, 2022
In adult skeletal muscle, satellite cells are in a quiescent state, which is essential for the future activation of muscle homeostasis and regeneration.
Wenzhe Luo, Yueyuan Xu, Ruige Liu, Yinlong Liao, Sheng Wang, Haoyuan Zhang, Xinyun Li, Heng Wang   +7 more
doaj   +1 more source

Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. [PDF]

PLoS ONE, 2007
Retinoic acid (RA), the bioactive derivative of Vitamin A, by epigenetically controlling transcription through the RA-receptors (RARs), exerts a potent antiproliferative effect on human cells.
Giulia Somenzi, Giusy Sala, Stefano Rossetti, MingQiang Ren, Riccardo Ghidoni, Nicoletta Sacchi   +5 more
doaj   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Molecular Characterization of Retinoic Acid Receptor CgRAR in Pacific Oyster (Crassostrea gigas)

Frontiers in Physiology, 2021
Retinoic acid (RA) signaling pathways mediated by RA receptors (RARs) are essential for many physiological processes such as organ development, regeneration, and differentiation in animals.
Kaidi Jin, Qianqian Jin, Zhongqiang Cai, Baoyu Huang, Lei Wei, Meiwei Zhang, Wen Guo, Yaqiong Liu, Xiaotong Wang   +8 more
doaj   +1 more source

A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter [PDF]

Molecular Endocrinology, 1990
The morphogen retinoic acid (RA) regulates gene transcription by interacting with specific nuclear receptors that recognize DNA sequences near responsive promoters. While much has recently been learned about the nuclear receptor proteins, little is known about the genes that are directly regulated by RA and their cis-acting response elements recognized
B, Hoffmann, J M, Lehmann, X K, Zhang, T, Hermann, M, Husmann, G, Graupner, M, Pfahl   +6 more
openaire   +2 more sources

Beta-carotene Reduces Body Adiposity of Mice Via BCMO1 [PDF]

, 2011
Evidence from cell culture studies indicates that ß-carotene-(BC)-derived apocarotenoid signaling molecules can modulate the activities of nuclear receptors that regulate many aspects of adipocyte physiology.
Yvonne G. J. van Helden, Georg Lietz, Kiec-Wilk, B., Andreu Palou, Adrian Wyss, von Lintig, J., Jean François Landrier, Landrier, Jean-Francois, Ursula Razny, Lietz, G., Raźny, Urszula, Kramer, E.H.M., Amengual, J., Wyss, A., Kramer, Evelien, Lietz, Georg, Gouranton, Erwan, M. Luisa Bonet, Razny, Ursula, Beata Kiec-Wilk, van Helden, Y.G., M Luisa Bonet, Joan Ribot, Susanne Hessel, Aldona Dembinska-Kiec, Jaap Keijer, Landrier, Jean François, Yvonne G J van Helden, Keijer, J., Hessel, S., Dembinska-Kiec, Aldona, Amengual, Jaume, Keijer, Jaap, Landrier, J. F., Bonet, M. Luisa, Ribot, Joan, Kramer, E., Dembinska-Kiec, A., Gouranton, E., Palou, Andreu, Kiec-Wilk, Beata, Ribot, J., Erwan Gouranton, Palou, A., Razny, U., Helden, Y.G.J., Johannes von Lintig, Wyss, Adrian, Hessel, Susanne, Evelien Kramer, van Helden, Yvonne G. J., Luisa Bonet, M., von Lintig, Johannes, Bonet, M.L., Jaume Amengual   +54 more
core   +1 more source

1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes.

, 1996
1,25 (OH)(2) Vitamin D-3 (VD3) and retinoic acid (RA) function as ligands for nuclear receptors which regulate transcription, Though the cardiovascular system is not thought to represent a classical target for these ligands, it is clear that both cardiac
Gardner, D. G., J Wu, Garami, Miklós, Cheng, T., T Cheng, Wu, J., M Garami, D G Gardner   +7 more
core   +1 more source