Results 211 to 220 of about 390,951 (380)

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

3D Quantification of Viral Transduction Efficiency in Living Human Retinal Organoids

Small Methods, EarlyView.
Optimization of viral vectors and their testing in human tissue is crucial to gene therapy development. Conventional technologies to assess virus transduction either lack spatial or temporal information. Here, spatiotemporal mapping of virus transduction in living retinal tissue is introduced, levering fluorescence imaging and machine learning‐based ...
Teresa S. Rogler, Katja A. Salbaum, Achim T. Brinkop, Selina M. Sonntag, Rebecca James, Elijah R. Shelton, Alina Thielen, Roland Rose, Sabrina Babutzka, Thomas Klopstock, Stylianos Michalakis, Friedhelm Serwane   +11 more
wiley   +1 more source

Signaling via retinoic acid receptors mediates decidual angiogenesis in mice and human stromal cell decidualization. [PDF]

FASEB J
Zhao Q, Samuels CA, Timmins P, Massri N, Chemerinski A, Wu T, Loia R, Cheung EK, Zhang X, Arora R, Babwah AV, Douglas NC.   +11 more
europepmc   +1 more source

Retinoic Acid Receptor β Expression and Growth Inhibition of Gynecologic Cancer Cells by the Synthetic Retinoid N-(4-Hydroxyphenyl) Retinamide [PDF]

, 1998
Anita L. Sabichi, Denver T. Hendricks, Mary A. Bober, Michael J. Birrer   +3 more
openalex   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

VIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou, Shuai Li, Qi Hou, Runjia Wang, Zhenghao Deng, Xiyuan Xu, Zhichao Li, Linhui Ma, Yuan Shen, Qidong Liu, Hui Zheng   +10 more
wiley   +1 more source

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. [PDF]

, 1997
Melissa C. Colbert, D. Greg Hall, Thomas R. Kimball, Sandra A. Witt, John N. Lorenz, Michael Kirby, Timothy E. Hewett, Raisa Klevitsky, Jeffrey Robbins   +8 more
openalex   +1 more source

Role of NRP1/HDAC4/CREB/RIPK1 Axis in SARS‐CoV2 S1 Spike Subunit‐Induced Neuronal Toxicity

FASEB BioAdvances, EarlyView.
Extracellular SARS‐CoV2 Spike‐S1 protein via NRP1 internalizes in the cytosol of SH‐SY5Y cells. Once inside, it upregulates the epigenetic eraser HDAC4, which binds transcriptional factor CREB, causes RIPK1 up‐regulation, and therefore necroptotic cell death.
Luca Sanguigno, Natascia Guida, Mariarosaria Cammarota, Silvia Ruggiero, Angelo Serani, Francesca Galasso, Vincenzo Pizzorusso, Francesca Boscia, Luigi Formisano   +8 more
wiley   +1 more source

Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells. [PDF]

Oncogene, 2017
Fettig LM, McGinn O, Finlay-Schultz J, LaBarbera DV, Nordeen SK, Sartorius CA.   +5 more
europepmc   +1 more source

Mechanistic Insights Into 5′‐tiRNA‐His‐GTG Mediated Activation of the JNK Pathway in Skin Photoaging

Aging Cell, EarlyView.
5′‐tiRNA‐His‐GTG expression level is upregulated in the photoaging cell model. 5′‐tiRNA‐His‐GTG negatively regulates the expression of NUP98, thereby activating the JNK signaling pathway to regulate cell senescence. ABSTRACT UV exposure leads to skin damage, thus inducing skin aging.
Lihao Liu, Zhuohong Xu, Xiaoxi Dai, Xuyue Zhou, Lihao Chen, Chao Luan, Dan Huang, Hongying Chen, Jiaan Zhang, Yu Hu, Kun Chen   +10 more
wiley   +1 more source