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Retinoic acid controls development and detoxification responses in the mussel Mytilus galloprovincialis despite loss of canonical RAR activity

Salatiello F, Miglioli A, Vitale RM, Tarallo V, Benvenuto G, Greco S, Carvalho JE, Pallavicini A, Dumollard R, Schubert M, Gerdol M, D'Aniello E.   +11 more
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Transcriptional Activities of Retinoic Acid Receptors

, 2005
Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid ...
Lefebvre, P., Martin, P.J., Flajollet, S., Dedieu, S., Billaut, X., Lefebvre, B.   +5 more
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RETINOIC ACID RECEPTORS AND CANCERS

Annual Review of Nutrition, 2004
▪ Abstract  Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention.
Kenneth J Soprano, Dianne Robert Soprano
exaly   +3 more sources

Retinoic acid and retinoic acid receptors in craniofacial development

Seminars in Cell and Developmental Biology, 1997
Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
Peter Thorogood, P Thorogood
exaly   +3 more sources

Retinoids, Retinoic Acid Receptors, and Cancer

Annual Review of Pathology: Mechanisms of Disease, 2011
Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids. Retinoid signaling is often compromised early in carcinogenesis, which suggests that a reduction in retinoid signaling may ...
Xiao-Han, Tang, Lorraine J, Gudas
openaire   +3 more sources

Retinoic acid and retinoic acid receptors in development

Molecular Neurobiology, 1995
The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family,
H M, Sucov, R M, Evans
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History of Retinoic Acid Receptors

2014
The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Benbrook, Doris M., Chambon, Pierre, Rochette-Egly, Cécile, Asson-Batres, Mary Ann   +3 more
openaire   +3 more sources