A Human Model of Oligodendrocyte Development Shows MCL‐1 Influences Oligodendrocyte Morphogenesis
A unified model of oligodendrocyte differentiation from human embryonic stem cells revealed that MCL‐1 is critical for regulating the expression of oligodendrocyte‐related genes and the morphogenesis of myelinating oligodendrocytes. ABSTRACT Oligodendrocytes are the myelinating cells of the central nervous system.
Melanie Gil +2 more
wiley +1 more source
Combination therapy based on venetoclax overcomes resistance to all-trans retinoic acid and arsenic trioxide in a variant acute promyelocytic leukemia with TNRC18::RARA fusion. [PDF]
Ding W +10 more
europepmc +1 more source
Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors
Evan D. Rosen +2 more
openalex +1 more source
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari +5 more
wiley +1 more source
Hyaluronic Acid‐Based, Double Network Hydrogels With Tunable Viscoelasticity for Neural Cell Culture
ABSTRACT Brain tissue is the softest, most viscoelastic tissue in mammals and these mechanical properties strongly influence cell phenotypes. However, conventional hydrogels for 3D cultures rarely provide the ability to tune the elasticity (G′) independently of the viscosity (G″), making it impossible to decouple the effects of each mechanical ...
Talia Sanazzaro +6 more
wiley +1 more source
Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała +3 more
wiley +1 more source
The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects. [PDF]
Wei L +8 more
europepmc +1 more source
Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice [PDF]
Yu Hou +10 more
openalex +1 more source
Beyond olfaction: New insights into human odorant binding proteins
Abstract Until today, the exact function of mammalian odorant binding proteins (OBPs) remains a topic of debate. Although their main established function lacks direct evidence in human olfaction, OBPs are traditionally believed to act as odorant transporters in the olfactory sense. Now, available RNA‐seq and proteomics data identified the expression of
Mifen Chen +5 more
wiley +1 more source

