Results 31 to 40 of about 349,317 (300)

Neofunctionalization in vertebrates: the example of retinoic acid receptors. [PDF]

PLoS Genetics, 2006
Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies.
Hector Escriva, Stéphanie Bertrand, Pierre Germain, Marc Robinson-Rechavi, Muriel Umbhauer, Jérôme Cartry, Marilyne Duffraisse, Linda Holland, Hinrich Gronemeyer, Vincent Laudet   +9 more
doaj   +1 more source

Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases

Frontiers in Cellular and Infection Microbiology, 2022
Pattern recognition receptors (PRRs) play critical roles in recognizing pathogen-derived nucleic acids and inducing innate immune responses, such as inflammation and type I interferon production.
Norisuke Kano, Guang Han Ong, Daisuke Ori, Taro Kawai   +3 more
doaj   +1 more source

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Nature Communications, 2017
Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and ...
Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad   +5 more
doaj   +1 more source

Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PDF]

PLoS ONE, 2010
Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer.
Shaoteng Han, Takuya Fukazawa, Tomoki Yamatsuji, Junji Matsuoka, Hiroyuki Miyachi, Yutaka Maeda, Mary Durbin, Yoshio Naomoto   +7 more
doaj   +1 more source

Expression of retinoid receptors during rabbit lung development

Animal, 2007
Rabbit lung is often used to study the pathophysiology of some congenital anomalies affecting the lung because its development is very comparable with that of human.
K. Coste, D. Gallot, G. Marceau, J. Jani, J. Deprest, A. Labbé, D. Lémery, V. Sapin   +7 more
doaj   +1 more source

The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice

Molecular Metabolism, 2022
Objective: The β-carotene oxygenase 1 (BCO1) is the enzyme responsible for the cleavage of β-carotene to retinal, the first intermediate in vitamin A formation. Preclinical studies suggest that BCO1 expression is required for dietary β-carotene to affect
Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. [PDF]

PLoS ONE, 2015
Retinoids have been shown to serve promising therapeutic agents for human cancers, e.g. the treatment of neuroblastoma. Synthetic retinoids, specific for particular retinoic acid (RA) receptors, are tested as new therapy strategies. In the present study,
Patrick Müller, Rebekka Doliva, Maike Busch, Claudia Philippeit, Harald Stephan, Nicole Dünker   +5 more
doaj   +1 more source

Naturally Occurring Eccentric Cleavage Products of Provitamin A β-Carotene Function as Antagonists of Retinoic Acid Receptors*

Journal of Biological Chemistry, 2012
Background: Dietary β-carotene can be cleaved centrally to vitamin A, an agonist of retinoic acid receptors, or eccentrically to yield β-apocarotenoids.
Abdulkerim Eroglu, Damian P. Hruszkewycz, Carlo C. dela Seña, Sureshbabu Narayanasamy, K. Riedl, R. Kopec, S. Schwartz, R. Curley, E. Harrison   +8 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source