Results 41 to 50 of about 390,951 (380)
Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. [PDF]
PLoS ONE, 2011 Dominant mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of Parkinson's disease, however, little is known about the biological function of LRRK2 protein.
Cathrin Schulz +7 more
doaj +1 more source
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]
, 2019 Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F. +3 more
core +1 more source
Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis [PDF]
International Journal of Ophthalmology, 2015 Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response.
Hong-Yan Zhou +5 more
doaj +1 more source
Vitamin A affects flatfish development in a thyroid hormone signaling and metamorphic stage dependent manner [PDF]
, 2017 Vitamin A (VA) and retinoid derivatives are known morphogens controlling vertebrate development. Despite the research effort conducted during the last decade, the precise mechanism of how VA induces post-natal bone changes, and particularly those ...
Balmer +73 more
core +3 more sources
PLoS ONE, 2011 BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong +8 more
doaj +1 more source
Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PDF]
PLoS ONE, 2010 Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer.
Shaoteng Han +7 more
doaj +1 more source
Molecular Imaging, 2004 Retinoic acids are natural derivatives of vitamin A, and play important roles in modulating tumor cell growth by regulating differentiation, thus suggesting the potential use of these derivatives in cancer therapy and prevention.
Min Kyung So +8 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Pattern recognition receptors (PRRs) play critical roles in recognizing pathogen-derived nucleic acids and inducing innate immune responses, such as inflammation and type I interferon production.
Norisuke Kano +3 more
doaj +1 more source
Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. [PDF]
, 2010 An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression.
Amengual, J. +9 more
core +2 more sources
Frontiers in Oncology, 2022 Acute promyelocytic leukemia (APL) accounts for 10–15% of newly diagnosed acute myeloid leukemias (AML) and is typically caused by the fusion of promyelocytic leukemia with retinoic acid receptor α (RARA) gene.
Luca Guarnera +13 more
doaj +1 more source