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Teratology of Retinoids

Annual Review of Pharmacology and Toxicology, 1999
Either an excess or a deficiency of vitamin A and related compounds (retinoids) causes abnormal morphological development (teratogenesis). Potential retinoid sources come from dietary intake, nutritional supplements, and some therapeutic drugs. Therefore, understanding the mechanisms of retinoid teratogenesis is important.
Michael D. Collins, Gloria E. Mao
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Retinoids and photodamage

British Journal of Dermatology, 1992
Extensive well-controlled clinical studies performed over the past 5 years have demonstrated a consistent, dose-dependent, statistically significant improvement in the appearance of photodamaged skin after 3-6 months of daily treatment with topical 0.001-0.1% tretinoin cream.
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Retinoids and the Skin

Nutrition Reviews, 2009
Retinoids are a group of naturally occurring and synthetic compounds with vitamin A-like biological activity. They play an important role in vision, reproduction, growth, and epithelial cell differentiation. Recent discoveries of specific retinoid cellular binding proteins and nuclear receptors have led to a better (although not complete) understanding
Barbara A. Gilchrest, Tanya Futoryan
openaire   +3 more sources

Retinoid receptors and therapeutic applications of RAR/RXR modulators.

Current Topics in Medicinal Chemistry, 2012
Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth, differentiation, survival and death.
A. le Maire   +5 more
semanticscholar   +1 more source

Retinoid Specificity of Interphotoreceptor Retinoid-Binding Protein

Biochemistry, 1994
Interphotoreceptor retinoid-binding protein (IRBP), the predominant protein in the interphotoreceptor matrix of retina, has been implicated in transfer of retinoids between retinal pigment epithelium and photoreceptor cells. In this work, the interactions of several retinoids with IRBP were studied in order to clarify whether the protein displays ...
Yong Chen, Noa Noy
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Retinoids in Chemoprevention

European Urology, 1999
Over several decades, in vitro experimental studies have demonstrated that retinoids effect the process of carcinogenesis and tend towards the alteration of cells back to more normal differentiation. This hypothesis has formed the basis of several chemopreventive studies in breast cancer, cervical cancer, head and neck cancer and lung cancer ...
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Retinoids and Ageing

Hormone Research, 1995
The observation that topical retinoic acid could attenuate wrinkles and other features of skin photoageing has projected this molecule into the media spotlight. Behind this effect are in fact major basic biological issues related to the role of retinoids in tissue maintenance and their possible interference with the molecular biology of cellular ageing.
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Retinoid Receptors

Dermatologic Clinics, 2007
"Retinoid" refers to the naturally occurring compounds with vitamin A activity and to synthetic analogues of retinol. Retinoids are key regulators of differentiation, proliferation, and inflammation. Their successful use in the treatment of various skin diseases and neoplasias has revolutionized the practice of dermatology as well as oncology.
Batya B, Davidovici   +2 more
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Retinoids and cancer

Cancer Chemotherapy and Pharmacology, 1979
The early and recent investigations in the field of retinoids and cancer are reviewed. The retinoids, including natural vitamin A compounds and their synthetic analogs, present a new class of substances exerting a prophylactic and a therapeutic effect both in certain experimental tumor models and in certain clinical conditions of preneoplastic and ...
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Retinoids: A review

Journal of the American Academy of Dermatology, 1984
The retinoids are synthetic derivatives of vitamin A. Isotretinoin (13-cis-retinoic acid) is now being widely used in the United States for severe acne and etretinate is available in Europe and other countries for psoriasis. These drugs are also effective for a number of other skin diseases.
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