Results 291 to 300 of about 155,897 (329)

Retinoid-X receptor signalling in the developing spinal cord

Nature, 1998
Retinoids regulate gene expression through the action of retinoic acid receptors (RARs) and retinoid-X receptors (RXRs), which both belong to the family of nuclear hormone receptors. Retinoids are of fundamental importance during development, but it has been difficult to assess the distribution of ligand-activated receptors in vivo.
Ludmila Solomin, Urban Lendahl, Thomas Perlmann, Clas B. Johansson, Richard A. Heyman, Reid P. Bissonnette, Rolf Zetterström, Jonas Frisén, Lars Olson   +8 more
openaire   +3 more sources

Characterization of synthetic retinoids with selectivity for retinoic acid or retinoid X nuclear receptors

Biochimica et Biophysica Acta (BBA) - General Subjects, 1996
The broad spectrum of physiological activities of retinoids is mediate d by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). Though they have 9-cis retinoic acid as a common ligand, the amino acid sequence of their ligand binding domains is only distantly related (27%). This fact makes it probable that the
Christian M. Apfel, Peter K. Lemotte, Siegfried Keidel   +2 more
openaire   +3 more sources

Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.

Journal of Natural Products, 2010
Screening of a total of 86 crude drugs for retinoid X receptor (RXR) ligands demonstrated that the methanol extract of the bark of Magnolia obovata markedly activated the transcriptional activity of RXRalpha in luciferase reporter assays.
H. Kotani, H. Tanabe, H. Mizukami, M. Makishima, M. Inoue   +4 more
semanticscholar   +1 more source

Vitamin D receptor and retinoid X receptor interactions in motion

2002
Vitamin D receptor (VDR) and retinoid X receptor (RXR) are members of the nuclear receptor superfamily and they bind target DNA sequences as heterodimers to regulate transcription. This article surveys the latest findings regarding the roles of dimerizing RXR in VDR function and emphasizes potential areas for future developments. We first highlight the
K Prufer, J Barsony
openaire   +3 more sources

Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor

Biochemical and Biophysical Research Communications, 2006
Mutations in the human ABCC6 gene are responsible for the disease pseudoxanthoma elasticum, although the physiological function or substrate of the gene product (an ABC transporter known also as MRP6) is not known. We found that the expression of this gene in cells of hepatic origin (where this gene is predominantly expressed in the body) is ...
Lukasz Pulaski, Grzegorz Bartosz, Marcin Ratajewski   +2 more
openaire   +3 more sources

Retinoid X receptor and its partners in the nuclear receptor family

Current Opinion in Structural Biology, 2001
Retinoid X receptor (RXR) and its dimerization partners in the nuclear receptor family recognize DNA response elements in which two AGGTCA binding sites are arranged in tandem. Target site selection by these complexes requires the spacing between the binding sites to act as the identity element.
openaire   +3 more sources

Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

Journal of Medicinal Chemistry, 1994
Two series of potent retinoid X receptor (RXR)-selective compounds were designed and synthesized based upon recent observation that (E)-4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1- propenyl]benzoic acid (TTNBP) binds and transactivates only the retinoic acid receptor (RAR) subtypes whereas (E)-4-[2-(3,5,5,8,8-pentamethyl-5,6,7,8 ...
Dale E. Mais, Marcus F. Boehm, Elaine M. Berger, Mark E. Goldman, Lin Zhang, Richard A. Heyman, Carla M. Suto, Steven K. White, Beth Ann Badea   +8 more
openaire   +3 more sources

Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.

Journal of Medicinal Chemistry, 1995
Structural modifications of the retinoid X receptor (RXR) selective compound 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2- naphthyl)ethenyl]benzoic acid (LGD1069), which is currently in phase I/IIA clinical trials for cancer and dermatological ...
M. Boehm, Lin Zhang, L. Zhi, M. McClurg, Elaine M. Berger, M. Wagoner, Dale E. Mais, Carla M. Suto, Peter J. A. Davies, Richard A. Heyman, A. Nadzan   +10 more
semanticscholar   +1 more source

Identification of the First Retinoid X Receptor Homodimer Antagonist

Journal of Medicinal Chemistry, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Richard A. Heyman, Dardashti Laura J, Glenn Croston, Alex M. Nadzan, Karen S. Flatten, Jonathan J. Hebert, Steven K. White, Stacie S. Canan Koch   +7 more
openaire   +4 more sources

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

Cell, 1992
R. Heyman, D. Mangelsdorf, J. Dyck, R. Stein, G. Eichele, R. Evans, C. Thaller   +6 more
semanticscholar   +1 more source