Results 111 to 120 of about 6,100,826 (198)

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
PRAME promotes SACC invasion and metastasis by inducing EMT via Twist1 upregulation and by destabilizing RARα through Cullin2‑mediated ubiquitination, a mechanism that may limit ATRA efficacy. In vivo, PRAME enhances subcutaneous growth and lung metastasis, highlighting its oncogenic role in SACC.
Xudong Wang, Tingyao Ma, Yixin Jing, Tianyi Li, Xi Zhao, Guohan Zhao, Ran Gao, Lu Kong, Xiaohong Chen   +8 more
wiley   +1 more source

Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms

, 2005
We have investigated the role of Vitamin A (retinoid) proteins in hepatic retinoid processing under normal conditions and during chemical stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a chemical known to interfere with retinoid turnover ...
Hoegberg, P., Fletcher, N., Fletcher, N, Ghyselinck, N.B., Schmidt, CK, Chambon, P, Hakansson, H., Trossvik, C., Brouwer, A, Schmidt, C.K., Nau, H., Ghyselinck, NB, Hoegberg, P, Nilsson, CB, Schuur, AG, Nau, H, Brouwer, A., Trossvik, C, Nilsson, C.B., Gerlienke Schuur, A.   +19 more
core   +1 more source

Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia, Chang Liang, Zhuoqing Zhuang, Pingrun Chen, Zhe Xiong, Junzhu Lu, Yan Zhang   +6 more
wiley   +1 more source

A thermodynamic model of RXR self-association and ligand binding [PDF]

, 2014
This study looked at the thermodynamics of ligand binding to the Retinoid X Receptor (RXR) and the formation of the RXR auto-repressive tetramer. Often called the "Master Coordinator" RXR is a required partner for activation of class II nuclear receptors.
Healy, James Patrick, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Retinoid Receptors RAR and RXR: Structure and Function

, 2008
Originally published in: Cellular Proteins and Their Fatty Acids in Health and Disease. Edited by Asim K. Duttaroy and Friedrich Spener. Copyright © 2003 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim.
Perlmann, T, de, Urquiza AM
core   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal development: identification of potential heterodimeric receptors

, 1999
Vitamin A is required in the testis for germ cell development. It acts through two families of retinoid receptors, retinoic acid receptors (RAR) and retinoid X receptors (RXR), each with three subtypes a, b, and g.
Kwan Hee Kim, KWAN HEE KIM, KWAN HEE, DUFOUR, J. M, Jannette M. Dufour   +3 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ

Cell Communication and Signaling
The human retinoid X receptor γ (hRXRγ) is one of three characterized RXR subtypes, transcription factors belonging to the nuclear receptor superfamily. All RXR subtypes share nearly identical structural elements, including a conserved DNA-binding domain,
Katarzyna Sołtys, Krzysztof Skowronek, Dominika Bystranowska, Krzysztof Wycisk, Andrzej Ożyhar   +4 more
doaj   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego, Giuseppina Andreotti, Maria Monticelli, Debora Paris, Arturo Martín‐Martínez, Alejandra Gámez, Mercedes Serrano, José Córdoba‐Caballero, Pedro Seoane, Juan A. G. Ranea, Belén Pérez   +10 more
wiley   +1 more source