Results 101 to 110 of about 23,550 (202)

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 170-188, June 2026.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Functionally related internal fluctuations in human ileal bile acid‐binding protein by high pressure nuclear magnetic resonance

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Hidden protein states with partially unfolded regions can have a functional relevance and may also contribute to an uncontrolled self‐association of proteins leading to pathological conditions. Human ileal bile acid‐binding protein (hI‐BABP), a member of the family of intracellular lipid‐binding proteins (iLBPs), plays a key role in the ...
Tamara Teski, Bence Balterer, Gergő Horváth, Gábor Turczel, Orsolya Toke   +4 more
wiley   +1 more source

Inhibitory Effects of Litchi Extract on Sebum Secretion and Its Mechanism: Evidence From a Mouse Model and Sebaceous Gland Cell Transcriptomics

Journal of Cosmetic Dermatology, Volume 25, Issue 6, -Not available-.
ABSTRACT Objective Acne vulgaris is one of the most common chronic inflammatory dermatological disorders, affecting 85%–100% of adolescents and persisting into adulthood for a significant portion of the population. Litchi chinensis, a subtropical fruit originating from Southern China and famously associated with the Guangzhou region, is commercially ...
Qinqian Tao, Xingmei Chen, Xian Chen, Xiang Yang, Erping Yan   +4 more
wiley   +1 more source

Retinol‐Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration

Skin Research and Technology, Volume 32, Issue 6, June 2026.
ABSTRACT Background Functional cosmetic materials with anti‐aging properties, such as wrinkle reduction, often struggle to penetrate the skin's stratum corneum (skin barrier). Therefore, to exert anti‐aging effects, these materials must pass through the skin barrier and reach fibroblasts in the dermal layer.
Han‐woong Park, Dae‐Sung Yoo, Chan Jin Jeong, Soo Nam Park   +3 more
wiley   +1 more source

Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone‐Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This study investigates the role of the vision gene RGR using novel dual knockout zebrafish models. The loss of rgra and rgrb results in zebrafish larvae having reduced visual function and altered retinoid profiles under light but not dark conditions. The OKR phenotype is enhanced under higher light intensities.
Grace Ruddin, Tess McCann, Joanna J. Kaylor, Michelle M. Fox, John D. Fehilly, Rebecca Ward, Adam Faulkner, Ailís L. Moran, Kieran Wynne, Roxana A. Radu, Michael G. Monaghan, Stephen D. Thorpe, Gabriel H. Travis, Breandán N. Kennedy   +13 more
wiley   +1 more source

The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ

Cell Communication and Signaling
The human retinoid X receptor γ (hRXRγ) is one of three characterized RXR subtypes, transcription factors belonging to the nuclear receptor superfamily. All RXR subtypes share nearly identical structural elements, including a conserved DNA-binding domain,
Katarzyna Sołtys, Krzysztof Skowronek, Dominika Bystranowska, Krzysztof Wycisk, Andrzej Ożyhar   +4 more
doaj   +1 more source

Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease. [PDF]

Br J Pharmacol, 2019
Fitz NF, Nam KN, Koldamova R, Lefterov I.   +3 more
europepmc   +1 more source

Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism. [PDF]

Front Endocrinol (Lausanne), 2017
De Cosmo S, Mazzoccoli G.
europepmc   +1 more source

Retinoid X Receptor [PDF]

, 2020
openaire   +1 more source

Retinoic acids and nuclear receptor signaling in liver development: Pathogenic roles in liver diseases

Pediatric Discovery
Retinoic acid (RA) serves as a metabolic intermediate of vitamin A. It plays a crucial physiological role in regulating cell proliferation, differentiation, apoptosis, embryonic development, and immunomodulation.
Wen Jia, Yang Bi
doaj   +1 more source