Results 91 to 100 of about 23,550 (202)

Synergistic Interaction Between HPV‐16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Armando Chávez‐Ríos, Celina López‐Ruiz, Ian A. García‐Aguirre, Rodolfo Ocadiz‐Delgado, Francisco Garcia‐Sierra, Rogelio Hernández‐Pando, Solangy Lizcano‐Meneses, Patricio Gariglio   +7 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Preclinical PET Neuroimaging of [C]Bexarotene

Molecular Imaging, 2016
Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administration-approved
Benjamin H. Rotstein PhD, Michael S. Placzek PhD, Hema S. Krishnan PhD, Aleksandra Pekošak MPharm, Thomas Lee Collier PhD, Changning Wang PhD, Steven H. Liang PhD, Ethan S. Burstein PhD, Jacob M. Hooker PhD, Neil Vasdev PhD   +9 more
doaj   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Multi‐Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia

MedComm, Volume 7, Issue 6, June 2026.
Preeclampsia, a severe pregnancy‐induced disorder unique to humans, affects ∼5% of pregnancies globally. To understand the pathogenesis of preeclampsia, this study performed a comprehensive multi‐omics analysis of early pregnancy placental biopsies (chorionic villus samples) from pregnancies that later developed preterm/term preeclampsia, compared to ...
Ellen Menkhorst, Guannan Yang, Yimiao Yu, Leilani L. Santos, Wei Zhou, Argyro Syngelaki, Swati Varshney, Nicholas A. Williamson, Kaori Koga, Daniel Lorber Rolnik, Fabricio da Silva Costa, Kypros Nicolaides, Kim‐Anh Lê Cao, Evdokia Dimitriadis   +13 more
wiley   +1 more source

Pleiotropic immunoregulation by bile acids in pathophysiology

Frontiers in Immunology
Bile acids (BAs) have evolved from their classical role in lipid digestion to become central signaling molecules that integrate host metabolism, gut microbiota, and immune function.
Bo-Shen Lin, Min-Yue Yin, Si-An Xie, Peng Li, Xue Li   +4 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin

Cells
This study explores the impact of environmental pollutants on nuclear receptors (CAR, PXR, PPARα, PPARγ, FXR, and LXR) and their heterodimerization partner, the Retinoid X Receptor (RXR).
Yannick Dauwe, Lucile Mary, Fabiana Oliviero, Louise Dubois, Elodie Rousseau-Bacquie, Jelskey Gomez, Véronique Gayrard, Laïla Mselli-Lakhal   +7 more
doaj   +1 more source

2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors.

Endocrinology, 2023
Ren XM, Chang RC, Huang Y, Amorim Amato A, Carivenc C, Grimaldi M, Kuo Y, Balaguer P, Bourguet W, Blumberg B.   +9 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source