Results 221 to 230 of about 121,393 (276)

International Union of Pharmacology. LXIII. Retinoid X Receptors

Pharmacological Reviews, 2006
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma.
P. Germain, P. Chambon, G. Eichele, R. Evans, M. Lazar, M. Leid, Á. D. De Lera, R. Lotan, D. Mangelsdorf, H. Gronemeyer   +9 more
semanticscholar   +5 more sources

Synthesis of Novel Retinoid X Receptor-Selective Retinoids

The Journal of Organic Chemistry, 2001
Retinoids 1-5 have been identified as potent RXR agonists for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM). Highly convergent syntheses of 1-5 have been developed. The core tetrahydronaphthalene 7, employed in the synthesis of 1 and 2, was prepared in 98% yield using an AlCl(3)-catalyzed (0.03 equiv) Friedel ...
M M, Faul, A M, Ratz, K A, Sullivan, W G, Trankle, L L, Winneroski   +4 more
openaire   +3 more sources

Retinoids Selective for Retinoid X Receptor Response Pathways

Science, 1992
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding
J M, Lehmann, L, Jong, A, Fanjul, J F, Cameron, X P, Lu, P, Haefner, M I, Dawson, M, Pfahl   +7 more
openaire   +2 more sources

Aza-retinoids as novel retinoid X receptor-specific agonists

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Luc J, Farmer, Kristen S, Marron, Stacie S, Canan Koch, C K, Hwang, E Adam, Kallel, Lin, Zhi, Alex M, Nadzan, Dave W, Robertson, Youssef L, Bennani   +8 more
openaire   +2 more sources

Retinoid X receptors

The International Journal of Biochemistry & Cell Biology, 1997
Retinoids are metabolites of retinol (vitamin A), which act as signalling molecules in embryogenesis and as stimulators of cellular differentiation. The potency of retinoids as differentiating agents has led to their successful use in treating skin diseases and some forms of cancer.
openaire   +2 more sources

Retinoid X receptors and retinoid response in neuroblastoma cells

Journal of Cellular Biochemistry, 2002
AbstractRetinoic acid (RA) modulates differentiation and apoptosis of neural cells via RA receptors (RARs) and retinoid X receptors (RXRs). Neuroblastoma cells are potentially useful models for elucidating the molecular mechanisms of RA in neural cells, and responses to different isomers of RA have been interpreted in terms of differential homo‐ and ...
Rana, B., Veal, G.J., Pearson, A.D.J., Redfern, C.P.F.   +7 more
openaire   +3 more sources

Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids

Biochemical Pharmacology, 1995
One feature that contraindicates the wide therapeutic use of retinoids is their teratogenicity. Synthetic retinoids are distinguishable from each other on the basis of their partial or exclusive preference in binding and activation of all-trans retinoic acid receptors (RARs) or retinoid X receptors (RXRs). Using mouse embryo limb bud cells in micromass
H, Jiang, J D, Penner, R L, Beard, R A, Chandraratna, D M, Kochhar   +4 more
openaire   +2 more sources

Determinants of Retinoid X Receptor Transcriptional Antagonism

Journal of Medicinal Chemistry, 2004
The synthesis and bioactivity of the retinoid X receptor (RXR) antagonist 4-[(3'-n-butyl-5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-naphthalenyl)(cyclopropylidene)methyl]benzoic acid and several heteroatom-substituted analogues are described. Ligand design was based on the scaffold of the 3'-methyl RXR-selective agonist analogue and reports that
Claudio N, Cavasotto, Gang, Liu, Sharon Y, James, Peter D, Hobbs, Valerie J, Peterson, Ananyo A, Bhattacharya, Siva K, Kolluri, Xiao-kun, Zhang, Mark, Leid, Ruben, Abagyan, Robert C, Liddington, Marcia I, Dawson   +11 more
openaire   +2 more sources

Retinoid X Receptor Heterodimers in the Metabolic Syndrome

New England Journal of Medicine, 2005
The principal abnormalities of the metabolic syndrome are abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance, inflammation, and prothrombotic states.
Andrew I, Shulman, David J, Mangelsdorf
openaire   +4 more sources