Results 231 to 240 of about 121,393 (276)

Limited Degradation of Retinoid X Receptor by Calpain

Biochemical and Biophysical Research Communications, 1996
Recently, we have found two major physiological forms of retinoid X receptor alpha (RXR alpha): the mature 54 kDa RXR alpha and the truncated 44 kDa RXR alpha lacking a portion of N-terminal A/B domain in human and rodent livers. In this communication, we show that m-calpain was active to digest 54 kDa RXR alpha in the human hepatoma-derived cell line,
R, Matsushima-Nishiwaki, Y, Shidoji, S, Nishiwaki, H, Moriwaki, Y, Muto   +4 more
openaire   +2 more sources

Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers

Journal of Natural Medicines, 2019
Retinoid X receptor (RXR) ligands have a wide range of beneficial effects in mouse models of Alzheimer's disease (AD). Recently accumulated evidence suggests that early neuroinflammation may be a therapeutic target for AD treatment. We therefore investigated the anti-inflammatory effects of the prenylated flavanoids SPF1 and SPF2, which were previously
Wei, Wang, Ken-Ichi, Nakashima, Takao, Hirai, Makoto, Inoue   +3 more
openaire   +2 more sources

Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

Journal of Medicinal Chemistry, 1994
Two series of potent retinoid X receptor (RXR)-selective compounds were designed and synthesized based upon recent observation that (E)-4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1- propenyl]benzoic acid (TTNBP) binds and transactivates only the retinoic acid receptor (RAR) subtypes whereas (E)-4-[2-(3,5,5,8,8-pentamethyl-5,6,7,8 ...
M F, Boehm, L, Zhang, B A, Badea, S K, White, D E, Mais, E, Berger, C M, Suto, M E, Goldman, R A, Heyman   +8 more
openaire   +2 more sources

Cloning of crustacean ecdysteroid receptor and retinoid-X receptor gene homologs and elevation of retinoid-X receptor mRNA by retinoic acid

Molecular and Cellular Endocrinology, 1998
We report the cloning and analysis of ecdysteroid receptor (bpEcR) and retinoid-X receptor (UpRXR) cDNA homologs from the fiddler crab Uca pugilator. The deduced amino acid sequence of this crustacean EcR most closely resembles the insect EcRs within the DNA binding and ligand binding domains (LBDs).
A C, Chung, D S, Durica, S W, Clifton, B A, Roe, P M, Hopkins   +4 more
openaire   +2 more sources

Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity

Journal of Medicinal Chemistry, 1995
The natural retinoid 9-cis-retinoic acid is an activating ligand for both the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are members of the retinoid/thyroid hormone/steroid hormone family of nuclear receptor proteins that activate gene transcription through specific response elements.
M I, Dawson, L, Jong, P D, Hobbs, J F, Cameron, W R, Chao, M, Pfahl, M O, Lee, B, Shroot, M, Pfahl   +8 more
openaire   +2 more sources

Vitamin D receptor and retinoid X receptor interactions in motion

2002
Vitamin D receptor (VDR) and retinoid X receptor (RXR) are members of the nuclear receptor superfamily and they bind target DNA sequences as heterodimers to regulate transcription. This article surveys the latest findings regarding the roles of dimerizing RXR in VDR function and emphasizes potential areas for future developments. We first highlight the
J, Barsony, K, Prufer
openaire   +2 more sources

Retinoid receptors in human esophageal squamous cell carcinoma: Retinoid X receptor as a potent prognostic factor

Pathology International, 2011
Retinoids regulate cell proliferation and differentiation in normal and neoplastic tissue. These effects are mainly mediated by two types of nuclear retinoid receptors, retinoic acid receptors (RAR) and retinoid X receptors (RXR). RXR have been demonstrated to play important roles in esophageal carcinoma, but the expression of RXRβ and RXRγ has not ...
Fumiyoshi, Fujishima, Takashi, Suzuki, Yasuhiro, Nakamura, Yusuke, Taniyama, Katsuhiko, Ono, Akira, Sugawara, Shukiti, Miyazaki, Takuya, Moriya, Akira, Sato, Susumu, Satomi, Hironobu, Sasano   +10 more
openaire   +2 more sources

Immunolocalization of peroxisome proliferator-activated receptors and retinoid x receptors in the adult rat CNS

Neuroscience, 2004
S. Moreno, S. Farioli-Vecchioli, M. Ceru'   +2 more
semanticscholar   +1 more source

Lycopene-derived bioactive retinoic acid receptors/retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential.

Molecular Nutrition & Food Research, 2013
Gamze Aydemir, Yasamin Kasiri, Eszter Birta, G. Béke, A. Garcia, E. Bartók, R. Rühl   +6 more
semanticscholar   +1 more source

Retinoid X receptor and its partners in the nuclear receptor family

Current Opinion in Structural Biology, 2001
Retinoid X receptor (RXR) and its dimerization partners in the nuclear receptor family recognize DNA response elements in which two AGGTCA binding sites are arranged in tandem. Target site selection by these complexes requires the spacing between the binding sites to act as the identity element.
openaire   +2 more sources