Results 241 to 250 of about 122,450 (299)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma. [PDF]

Mol Oncol
Ramchatesingh B, Martinez Villarreal A, Lefrançois P, Gantchev J, Sivachandran S, Abou Setah S, Litvinov IV.   +6 more
europepmc   +1 more source

Effects Atra on MMP-9 Activity and Integrin Expression in Choriocarcinoma Culture Cell Line Bewo (ATCC CCL-98). [PDF]

Asian Pac J Cancer Prev
Nurseta T, Indrawan IWA, Gunawan DA, Pramudia Wardani KR.   +3 more
europepmc   +1 more source

Chromosomal localization of the human retinoid X receptors.

Genomics, 1994
The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively).
Alexandru Almasan, D. Mangelsdorf, E. Ong, Geoffrey M. Wahl, Ronald M. Evans   +4 more
semanticscholar   +4 more sources

Retinoid X receptors in macrophage biology [PDF]

Trends in Endocrinology & Metabolism, 2013
Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism.
Tamás Rőszer, M. Menéndez-Gutiérrez, Marta Cedenilla, M. Ricote   +3 more
semanticscholar   +5 more sources

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International Union of Pharmacology. LXIII. Retinoid X Receptors

Pharmacological Reviews, 2006
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma.
P. Germain, P. Chambon, G. Eichele, R. Evans, M. Lazar, M. Leid, Á. D. De Lera, R. Lotan, D. Mangelsdorf, H. Gronemeyer   +9 more
semanticscholar   +5 more sources

Retinoid X receptors and retinoid response in neuroblastoma cells

Journal of Cellular Biochemistry, 2002
AbstractRetinoic acid (RA) modulates differentiation and apoptosis of neural cells via RA receptors (RARs) and retinoid X receptors (RXRs). Neuroblastoma cells are potentially useful models for elucidating the molecular mechanisms of RA in neural cells, and responses to different isomers of RA have been interpreted in terms of differential homo‐ and ...
Rana, B., Veal, G.J., Pearson, A.D.J., Redfern, C.P.F.   +7 more
openaire   +4 more sources

Retinoids Selective for Retinoid X Receptor Response Pathways

Science, 1992
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding
James F. Cameron, Ling Jong, Magnus Pfahl, Xian Ping Lu, Marcia I. Dawson, Pamela Haefner, Jürgen M. Lehmann, Andrea Fanjul   +7 more
openaire   +3 more sources

Lycopene-derived bioactive retinoic acid receptors/retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential.

Molecular Nutrition & Food Research, 2013
Dietary consumption of tomato products and especially the red tomato pigment lycopene has been associated with lower risk of cancer. New evidence is emerging toward metabolic pathways mediating the anti-cancer activities of lycopene.
Gamze Aydemir, Yasamin Kasiri, Eszter Birta, G. Béke, A. Garcia, E. Bartók, R. Rühl   +6 more
semanticscholar   +1 more source

ChemInform Abstract: Synthesis of Novel Retinoid X Receptor‐Selective Retinoids.

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Leonard L. Winneroski, Kevin A. Sullivan, William G. Trankle, Margaret M. Faul, Andrew Michael Ratz   +4 more
openaire   +4 more sources

Identification of an Activator of the Retinoid X Receptor

Journal of Natural Products, 1994
A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.
Charles Pathirana, Richard A. Heyman, Steven B. Lazarchik   +2 more
openaire   +3 more sources