Results 261 to 270 of about 122,450 (299)

Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors.

Endocrinology, 1993
Thyroid hormone receptor (TR) binding to thyroid hormone response elements is enhanced by heterodimerization with T3 receptor auxiliary proteins (TRAPs).
A. Sugawara, P. Yen, D. Darling, W. Chin
semanticscholar   +1 more source

Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity

Journal of Medicinal Chemistry, 1995
The natural retinoid 9-cis-retinoic acid is an activating ligand for both the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are members of the retinoid/thyroid hormone/steroid hormone family of nuclear receptor proteins that activate gene transcription through specific response elements.
M I, Dawson, L, Jong, P D, Hobbs, J F, Cameron, W R, Chao, M, Pfahl, M O, Lee, B, Shroot, M, Pfahl   +8 more
openaire   +3 more sources

Retinoic acid receptors and retinoid X receptors in the mature retina: subtype determination and cellular distribution.

Current Eye Research, 1999
PURPOSE In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina.
J. Janssen, E. Kuhlmann, A. V. van Vugt, H. Winkens, B. P. Janssen, A. Deutman, C. Driessen   +6 more
semanticscholar   +1 more source

Retinoid-X receptor signalling in the developing spinal cord

Nature, 1998
Retinoids regulate gene expression through the action of retinoic acid receptors (RARs) and retinoid-X receptors (RXRs), which both belong to the family of nuclear hormone receptors. Retinoids are of fundamental importance during development, but it has been difficult to assess the distribution of ligand-activated receptors in vivo.
Ludmila Solomin, Urban Lendahl, Thomas Perlmann, Clas B. Johansson, Richard A. Heyman, Reid P. Bissonnette, Rolf Zetterström, Jonas Frisén, Lars Olson   +8 more
openaire   +3 more sources

Characterization of synthetic retinoids with selectivity for retinoic acid or retinoid X nuclear receptors

Biochimica et Biophysica Acta (BBA) - General Subjects, 1996
The broad spectrum of physiological activities of retinoids is mediate d by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). Though they have 9-cis retinoic acid as a common ligand, the amino acid sequence of their ligand binding domains is only distantly related (27%). This fact makes it probable that the
Christian M. Apfel, Peter K. Lemotte, Siegfried Keidel   +2 more
openaire   +3 more sources

Vitamin D receptor and retinoid X receptor interactions in motion

2002
Vitamin D receptor (VDR) and retinoid X receptor (RXR) are members of the nuclear receptor superfamily and they bind target DNA sequences as heterodimers to regulate transcription. This article surveys the latest findings regarding the roles of dimerizing RXR in VDR function and emphasizes potential areas for future developments. We first highlight the
K Prufer, J Barsony
openaire   +3 more sources

Thyroid hormone affects the gene expression of retinoid X receptors in the adult rat.

Biochemical and Biophysical Research Communications - BBRC, 1993
Gene expression of three nuclear retinoid X receptors (RXR alpha, beta and gamma) was examined by Northern blot analysis in various rat tissues. The RXR alpha mRNA (5.5 kb) was detected in most tissues and particularly expressed at a high level in the ...
H. Mano, T. Ozawa, K. Takeyama, Y. Yoshizawa, R. Kojima, S. Kato, S. Masushige   +6 more
semanticscholar   +1 more source

Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor

Biochemical and Biophysical Research Communications, 2006
Mutations in the human ABCC6 gene are responsible for the disease pseudoxanthoma elasticum, although the physiological function or substrate of the gene product (an ABC transporter known also as MRP6) is not known. We found that the expression of this gene in cells of hepatic origin (where this gene is predominantly expressed in the body) is ...
Lukasz Pulaski, Grzegorz Bartosz, Marcin Ratajewski   +2 more
openaire   +3 more sources

Retinoid X receptor and its partners in the nuclear receptor family

Current Opinion in Structural Biology, 2001
Retinoid X receptor (RXR) and its dimerization partners in the nuclear receptor family recognize DNA response elements in which two AGGTCA binding sites are arranged in tandem. Target site selection by these complexes requires the spacing between the binding sites to act as the identity element.
openaire   +3 more sources

Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

Journal of Medicinal Chemistry, 1994
Two series of potent retinoid X receptor (RXR)-selective compounds were designed and synthesized based upon recent observation that (E)-4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1- propenyl]benzoic acid (TTNBP) binds and transactivates only the retinoic acid receptor (RAR) subtypes whereas (E)-4-[2-(3,5,5,8,8-pentamethyl-5,6,7,8 ...
Dale E. Mais, Marcus F. Boehm, Elaine M. Berger, Mark E. Goldman, Lin Zhang, Richard A. Heyman, Carla M. Suto, Steven K. White, Beth Ann Badea   +8 more
openaire   +3 more sources