Results 81 to 90 of about 2,216,238 (221)

Developmental changes in circulatory vitamin A (retinol) and its transport proteins in free-ranging harbour seal (Phoca vitulina) pups

open access: yes, 2000
Although vitamin A (retinol) levels are highly regulated within individual organisms, natural (e.g., age, sex, disease) and anthropogenic (e.g., environmental contaminants) factors can affect the dynamics of this essential nutrient.
Peter S Ross, Wendy Simms
core   +1 more source

Essential Oils From the Fruit of Amomum villosum Lour. Alleviate LPS‐Induced Neuroinflammation by Repressing PI3K‐Akt and MAPK Signaling Pathways

open access: yesPhytotherapy Research, EarlyView.
Amomum villosum essential oil (AVEO) alleviates LPS‐induced neuroinflammation and cognitive and behavioral dysfunction by suppressing PI3K‐Akt and MAPK signaling pathways, modulating inflammatory responses, and restoring metabolic homeostasis, thereby exerting neuroprotective effects. ABSTRACT Amomum villosum Lour.
Hongjin Wang   +11 more
wiley   +1 more source

Retinol-Binding Protein Interferes with Transthyretin-Mediated β‑Amyloid Aggregation Inhibition

open access: yes, 2018
β-Amyloid (Aβ) aggregation is causally linked to Alzheimer’s disease. On the basis of in vitro and transgenic animal studies, transthyretin (TTR) is hypothesized to provide neuroprotection against Aβ toxicity by binding to Aβ and inhibiting its ...
Regina M. Murphy   +3 more
core   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Vitamin A and retinol-binding protein metabolism during fetal development in the rat.

open access: yes, 1977
Studies were conducted on the metabolism and placental transport of vitamin A and plasma retinol-binding protein (RBP) during fetal development in the rat.
D S Goodman, J E Smith, Y I Takahashi
core   +1 more source

Retinol-binding protein 4 in skeletal and cardiac muscle: molecular mechanisms, clinical implications, and future perspectives

open access: yesFrontiers in Cell and Developmental Biology
Retinol-binding protein 4 (RBP4) has emerged as a critical adipokine involved in the pathophysiology of metabolic and cardiovascular diseases. Beyond its classical role in retinol transport, RBP4 influences insulin resistance, inflammation, lipid ...
Kangzhen Zhang   +3 more
doaj   +1 more source

Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat

open access: yesJournal of Lipid Research, 1975
Vitamin A is normally transported in plasma as retinol bound to a specific protein, retinol-binding protein (RBP). Detailed studies were conducted to examine the effects of excess vitamin A on the plasma concentration and metabolism of RBP, and to obtain
A.K. Mallia, J.E. Smith, D.W. Goodman
doaj   +1 more source

Husbandry factors are associated with skin, gastrointestinal and ophthalmic disorders in leopard geckos (Eublepharis macularius)

open access: yesVeterinary Record, EarlyView.
Abstract Background Research into disorders in captive reptiles is notably sparse in the UK, despite the popularity of various species as pets. This study aimed to survey and investigate risk factors for disorders of leopard geckos in the UK. Methods Medical records for leopard geckos presenting at three veterinary practices between 2019 and 2023 were ...
Joshua Henley, Tom Dutton, Joanna Hedley
wiley   +1 more source

Iterative phase retrieval in macromolecular crystal diffraction using the gradients of intensities

open access: yesJournal of Applied Crystallography, EarlyView.
Incorporating molecular intensity gradients into an iterative projection algorithm enables model‐free electron‐density reconstruction even for low‐solvent macromolecular crystals.Iterative phase retrieval (IPR) offers a model‐independent route to crystallographic structure determination but is fundamentally limited by the sampling of the diffraction ...
Sebastian Bielfeldt   +3 more
wiley   +1 more source

Meeting society's transport needs under tight budgets [PDF]

open access: yes, 2011
In the aftermath of the 2008 financial crisis, both the private and public sectors face stringent constraints in funding for transport infrastructure investment and transport services.
International Transport Forum, OECD
core   +1 more source

Home - About - Disclaimer - Privacy