Results 21 to 30 of about 16,020 (245)
Eco-evolutionary significance of domesticated retroelements in microbial genomes
Mobile DNA, 2022 Since the first discovery of reverse transcriptase in bacteria, and later in archaea, bacterial and archaeal retroelements have been defined by their common enzyme that coordinates diverse functions.
Blair G. Paul, A. Murat Eren
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Linking Retroelements to Autoimmunity [PDF]
Cell, 2008 In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.
Bhoj, Vijay G., Chen, Zhijian J.
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Does selection against transcriptional interference shape retroelement-free regions in mammalian genomes? [PDF]
PLoS ONE, 2008 BACKGROUND: Eukaryotic genomes are scattered with retroelements that proliferate through retrotransposition. Although retroelements make up around 40 percent of the human genome, large regions are found to be completely devoid of retroelements.
Tobias Mourier, Eske Willerslev
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Frontiers in Microbiology, 2021 The human genome bears evidence of extensive invasion by retroviruses and other retroelements, as well as by diverse RNA and DNA viruses. High frequency of somatic integration of the RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Anastasiya Kazachenka +2 more
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The evidence for increased L1 activity in the site of human adult brain neurogenesis. [PDF]
PLoS ONE, 2015 Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention.
Alexey A Kurnosov +9 more
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SETDB1-Mediated Silencing of Retroelements [PDF]
Viruses, 2020 SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 methyltransferases, SETDB1 and SETDB1-mediated H3K9 trimethylation (H3K9me3) play pivotal roles for silencing of endogenous and exogenous retroelements, thus contributing to genome ...
Kei Fukuda, Yoichi Shinkai
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Foldback Intercoil DNA and the Mechanism of DNA Transposition [PDF]
Genomics & Informatics, 2014 Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as 180° and the intertwining of two double helixes within each other's major groove to form an intercoil with a ...
Byung-Dong Kim
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Prospects of epigenetic therapy of head and neck squamous cell carcinoma
Опухоли головы и шеи, 2023 Introduction. Head and neck squamous cell carcinoma is the 6th most common malignant tumor. It is characterized by immune response evasion and drug resistance.
R. N. Mustafin
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Human Endogenous Retroviruses and Diseases. [PDF]
MedComm (2020)Human endogenous retroviruses (HERVs), remnants of ancient retroviral integrations into the human genome, are modulated by viral infections, genetic inheritance, and triggers including environmental factors, epigenetic dysregulation, oncogene activation, and aging.
Chen C +9 more
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LTR retroelements in the genome of
BMC Genomics, 2010 Background Long terminal repeat (LTR) retroelements represent a successful group of transposable elements (TEs) that have played an important role in shaping the structure of many eukaryotic genomes.
Kim Sun +5 more
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