Results 141 to 150 of about 995,941 (287)
Animal Models and Experimental Medicine, EarlyView.In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li +11 more
wiley +1 more source
Arthroscopy, EarlyView.Purpose To evaluate outcomes (graft failure, Patient‐Reported Outcome Measures, and knee stability) after primary isolated anterior cruciate ligament (ACL) reconstruction using the all‐inside technique with 4‐stranded semitendinosus autograft fixed between 2 adjustable‐loop cortical suspension devices, with a minimum follow‐up of 10 years.
Maxime Wolf +4 more
wiley +1 more source
Yeast retrograde signaling pathway between mitochondria and the nucleus
, 2014 Retrograde signaling pathway is the pathway between mitochondria and nucleus. This pathway helps Saccharomyces cerevisiae to cope with worsening of conditions of life, such as depletion of rich nutrient sources and necessity of use poor resources ...
Podholová, Kristýna
core
What's a White Matter ‘Fiber’?
Clinical Anatomy, EarlyView.ABSTRACT White matter anatomy is investigated using methods that operate at markedly different spatial scales and rely on distinct biological and physical principles. Nevertheless, the term “fiber” is routinely applied to the outputs of tract‐tracing studies, diffusion MRI tractography, and postmortem fiber dissection, often as though these entities ...
Guillaume Dannhoff +3 more
wiley +1 more source
Cereal Chemistry, EarlyView.ABSTRACT Background and Objectives Whole‐grain (brown) rice has superior nutritional quality but is prone to rancidity, primarily caused by endogenous lipases and oxidases. This study evaluated mild hydrothermal stabilization (MHS), comprising grain surface wetting, followed by short‐duration atmospheric‐pressure steaming, applied to two West African ...
Sali A. Ndindeng +5 more
wiley +1 more source
In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans
Cytoskeleton, EarlyView.ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley +1 more source
Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1
Cytoskeleton, EarlyView.ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley +1 more source
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Labeling Strategies for Monitoring Cytoskeleton Dynamics in Cultured Epithelial Cells
Cytoskeleton, EarlyView.ABSTRACT Collective cell migration relies on coordinated cytoskeletal remodeling, yet the impact of live‐cell actin filament probes on these dynamics remains poorly characterized. Here, we systematically compared the performance and cellular effects of fluorogenic jasplakinolide‐based probes, SiR‐actin and SiR‐XActin, with the genetically encoded ...
Victoria Levario‐Diaz +6 more
wiley +1 more source
Hyperactive KIF5A in Neurodegeneration
Cytoskeleton, EarlyView.ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos +1 more
wiley +1 more source