Results 131 to 140 of about 49,871 (252)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Fatty Acid-Binding Protein 5 Modulates Brain Endocannabinoid Tone and Retrograde Signaling in the Striatum. [PDF]

Front Cell Neurosci, 2022
Fauzan M, Oubraim S, Yu M, Glaser ST, Kaczocha M, Haj-Dahmane S.   +5 more
europepmc   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Protein phosphatase 2A-B55β mediated mitochondrial p-GPX4 dephosphorylation promoted sorafenib-induced ferroptosis in hepatocellular carcinoma via regulating p53 retrograde signaling. [PDF]

Theranostics, 2023
Qian B, Che L, Du ZB, Guo NJ, Wu XM, Yang L, Zheng ZX, Gao YL, Wang MZ, Chen XX, Xu L, Zhou ZJ, Lin YC, Lin ZN.   +13 more
europepmc   +1 more source

Retrograde neurotrophin signalling

Reactome - a curated knowledgebase of biological pathways, 2008
S Nasi, D Annibali
openaire   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Retrograde signaling is required for Slm35-mediated negative regulation of mitophagy in yeast. [PDF]

Biol Open
Ruelas-Ramírez H, Mendoza-Martínez AE, Medina-Flores PA, Funes S.   +3 more
europepmc   +1 more source

Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation. [PDF]

PLoS Genet, 2022
Rubio-Ferrera I, Baladrón-de-Juan P, Clarembaux-Badell L, Truchado-Garcia M, Jordán-Álvarez S, Thor S, Benito-Sipos J, Monedero Cobeta I.   +7 more
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson's disease. [PDF]

Front Aging Neurosci
Zeng F, Li W, Yang L, Yao L, Wang X.
europepmc   +1 more source