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Exogenous Coronavirus Interacts With Endogenous Retrotransposon in Human Cells
Frontiers in Cellular and Infection Microbiology, 2021 There is an increased global outbreak of diseases caused by coronaviruses affecting respiratory tracts of birds and mammals. Recent dangerous coronaviruses are MERS-CoV, SARS-CoV, and SARS-CoV-2, causing respiratory illness and even failure of several ...
Ying Yin +10 more
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Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. [PDF]
PLoS Genetics, 2017 Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity.
Kota Inoue +4 more
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Retrotransposon-induced mosaicism in the neural genome [PDF]
Open Biology, 2018 Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain ...
Gabriela O. Bodea +2 more
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Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription
Science, 2023 Non–long terminal repeat (non-LTR) retrotransposons, or long interspersed nuclear elements (LINEs), are an abundant class of eukaryotic transposons that insert into genomes by target-primed reverse transcription (TPRT). During TPRT, a target DNA sequence
Max E Wilkinson, Rhiannon K Macrae
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Nature Communications, 2019 A complete and accurate genome sequence provides a fundamental tool for functional genomics and DNA-informed breeding. Here, we assemble a high-quality genome (contig N50 of 6.99 Mb) of the apple anther-derived homozygous line HFTH1, including 22 ...
Jiang Hu +2 more
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Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells
Stem Cells International, 2018 Retrotransposons comprise a significant fraction of mammalian genome with unclear functions. Increasing evidence shows that they are not just remnants of ancient retroviruses but play important roles in multiple biological processes. Retrotransposons are
Ying Yin, Liquan Zhou, Shuiqiao Yuan
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The use of retrotransposon-based molecular markers to analyze genetic diversity [PDF]
Ratarstvo i Povrtarstvo, 2011 Molecular markers play an essential role in all aspects of genetics, modern plant breeding, in human forensics, for map-based cloning of genes, ranging from the identification of genes responsible for the desired traits to the management of backcrossing ...
Kalendar Ruslan
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Repeats as global DNA methylation marker in bovine preimplantation embryos [PDF]
Czech Journal of Animal Science, 2017 DNA methylation undergoes dynamic changes and is a crucial part of the epigenetic regulation during mammalian early development. To determine the DNA methylation levels in bovine embryos, we applied a bisulfite sequencing based method aimed at repetitive
Wenwen Li, Ann Van Soom, Luc Peelman
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How a Retrotransposon Exploits the Plant's Heat Stress Response for Its Activation
PLoS Genetics, 2014 Retrotransposons are major components of plant and animal genomes. They amplify by reverse transcription and reintegration into the host genome but their activity is usually epigenetically silenced.
Ortrun Mittelsten Scheid
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