Results 11 to 20 of about 50,973 (340)

Retrotransposons and Telomeres

Biochemistry (Moscow), 2023
Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle. Piwi proteins and Piwi-interacting RNAs (piRNAs) are key elements of the anti-transposon
Alla I, Kalmykova, Olesya A, Sokolova
openaire   +2 more sources

Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells. [PDF]

PLoS Genetics, 2013
Retrotransposon sequences are positioned throughout the genome of almost every eukaryote that has been sequenced. As mobilization of these elements can have detrimental effects on the transcriptional regulation and stability of an organism's genome, most
Andrew T Schuster, Kavitha Sarvepalli, Eain A Murphy, Michelle S Longworth   +3 more
doaj   +1 more source

The retrotransposon R2 maintains Drosophila ribosomal DNA repeats

bioRxiv, 2021
Ribosomal DNA (rDNA) loci contain the hundreds of tandemly repeated copies of ribosomal RNA genes needed to support cellular viability. This repetitiveness makes it highly susceptible to copy number (CN) loss, threatening multi-generational maintenance ...
Jonathan O. Nelson, Alyssa Slicko, Y. Yamashita   +2 more
semanticscholar   +1 more source

Advances in the pathogenesis of Rett syndrome using cell models

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022
Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley   +1 more source

InDelGT: An integrated pipeline for extracting indel genotypes for genetic mapping in a hybrid population using next‐generation sequencing data

Applications in Plant Sciences, Volume 10, Issue 6, November-December 2022., 2022
Abstract Premise Although several software packages are available for genotyping insertion/deletion (indel) polymorphisms in genomes using next‐generation sequencing data, simultaneously calling indel genotypes across many individuals for use in genetic mapping remains challenging. Methods and Results We present an integrated pipeline, InDelGT, for the
Zhiliang Pan, Jinpeng Zhang, Shengjun Bai, Zhiting Li, Chunfa Tong   +4 more
wiley   +1 more source

Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells. [PDF]

PLoS Computational Biology, 2012
Retrotransposons are highly prevalent in mammalian genomes due to their ability to amplify in pluripotent cells or developing germ cells. Host mechanisms that silence retrotransposons in germ cells and pluripotent cells are important for limiting the ...
Judith Reichmann, James H Crichton, Monika J Madej, Mary Taggart, Philippe Gautier, Jose Luis Garcia-Perez, Richard R Meehan, Ian R Adams   +7 more
doaj   +1 more source

A molecular marker set combining a retrotransposon insertion and SSR polymorphisms is useful for assessing diversity in Vitis

OENO One, 2021
Molecular markers, based on DNA polymorphisms, are useful tools for identifying individuals, establishing phylogenetic relationships, managing collections of genetic material or assisting breeding.
Frederique Pelsy, Lucie Bevilacqua, Sophie Blanc, Didier Merdinoglu   +3 more
doaj   +1 more source

Endosymbiotic ratchet accelerates divergence after organelle origin

BioEssays, Volume 45, Issue 1, January 2023., 2023
Primary endosymbiosis gave rise to mitochondria and plastids. The proximate impacts of organelle origin on lineage evolution have not been addressed at the population level. Using data from the photosynthetic amoeba Paulinella, we hypothesize that primary endosymbiosis accelerates lineage divergence, a process we refer to as the endosymbiotic ratchet ...
Debashish Bhattacharya, Julia Van Etten, L. Felipe Benites, Timothy G. Stephens   +3 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Comparative retrotransposon analysis of mutant and non-mutant rice varieties grown at different salt concentrations

Biotechnology & Biotechnological Equipment, 2022
This study investigated the effects of retrotransposon movements on the regeneration of 15- and 30-day-old leaves and roots of four different rice varieties grown in tissue culture medium at different salt concentrations (0, 50, 100, and 200 mmol/L) by ...
Yunus Emre Arvas, İsmail Kocaçalışkan, Emel Ordu, Semiha Erişen   +3 more
doaj   +1 more source