Results 21 to 30 of about 50,973 (340)
Frontiers in Genetics, 2021 In eukaryotic genomes, cycles of repeat expansion and removal lead to large-scale genomic changes and propel organisms forward in evolution. However, in conifers, active repeat removal is thought to be limited, leading to expansions of their genomes ...
Tony Heitkam +12 more
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Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline [PDF]
, 2013 The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable ...
A Aravin +241 more
core +1 more source
Current Biology, 2012 June 27, 1970 was a significant day for our understanding of both the flow of information in biological systems and the evolution of eukaryotic genomes as this was the day that Nature published back-to-back papers reporting the discovery of an enzyme that copies RNA into DNA. This soon became known as reverse transcriptase and the RNA tumour viruses in
openaire +2 more sources
Isolation of a transcriptionally active element of high copy number retrotransposons in sweetpotato genome [PDF]
, 2004 Many plant retrotransposons have been characterized, but only three families (Tnt1, Tto1 and Tos17) have been demonstrated to be transpositionally competent.
Aoki, Takahiro +6 more
core +1 more source
Nature Communications, 2019 A complete and accurate genome sequence provides a fundamental tool for functional genomics and DNA-informed breeding. Here, we assemble a high-quality genome (contig N50 of 6.99 Mb) of the apple anther-derived homozygous line HFTH1, including 22 ...
Liyi Zhang +20 more
semanticscholar +1 more source
Biomedicines, 2021 Small extracellular vesicles (SEVs) such as exosomes are released by multiple cell types. Originally believed to be a mechanism for selectively removing unwanted cellular components, SEVs have received increased attention in recent years for their ...
Marilou H. Barrios +5 more
doaj +1 more source
A Role for Retrotransposons in Chromothripsis [PDF]
, 2018 Chromothripsis is a mutational event driven by tens to hundreds of double-stranded DNA breaks which occur in a single event between a limited number of chromosomes. Following chromosomal shattering, DNA fragments are stitched together in a seemingly random manner resulting in complex genomic rearrangements including sequence shuffling, deletions, and ...
Dustin C. Hancks, Dustin C. Hancks
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Pathogens, 2021 While hybridization probe-based real-time PCR assays targeting highly repetitive multi-copy genome sequences for the diagnosis of S. mansoni complex or S.
Hagen Frickmann +13 more
doaj +1 more source
Roles for retrotransposon insertions in human disease
Mobile DNA, 2016 Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE insertions can result in single-gene disease in
Dustin C. Hancks, H. Kazazian
semanticscholar +1 more source
PLoS ONE, 2011 Transposable elements with long terminal direct repeats (LTR TEs) are one of the best studied groups of mobile elements. They are ubiquitous elements present in almost all eukaryotic genomes. Their number and state of conservation can be a highlight of genome dynamics.
Marta Hoffman-Sommer +2 more
openaire +5 more sources