Results 51 to 60 of about 25,174 (246)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

TUT-TUTting retrotransposons [PDF]

Nature Reviews Molecular Cell Biology, 2018
3′uridylation by TUT4 and TUT7 is shown as a post-transcriptional mechanism restricting retrotransposition of LINE-1 elements and also replication of animal RNA viruses.
openaire   +2 more sources

Characterization, Genomic Organization, Abundance, and Chromosomal Distribution of Ty1-copia Retrotransposons in Erianthus arundinaceus

Frontiers in Plant Science, 2017
Erianthus arundinaceus is an important wild species of the genus Saccharum with many valuable traits. However, the composition and structure of its genome are largely unknown, which have hindered its utilization in sugarcane breeding and evolutionary ...
Yongji Huang, Ling Luo, Xuguang Hu, Fan Yu, Yongqing Yang, Zuhu Deng, Zuhu Deng, Jiayun Wu, Jiayun Wu, Rukai Chen, Muqing Zhang   +10 more
doaj   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Isolation of a transcriptionally active element of high copy number retrotransposons in sweetpotato genome

, 2004
Many plant retrotransposons have been characterized, but only three families (Tnt1, Tto1 and Tos17) have been demonstrated to be transpositionally competent.
Yamashita, Hiroki, Tahara, Makoto, Suzuka, Shinya, Aoki, Takahiro, Tanaka, Masaru, Matsunaga, Sachi, Kokumai, Shuhei   +6 more
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Restricting retrotransposons: a review [PDF]

Mobile DNA, 2016
Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic "parasites", focussing on the non-long terminal repeat retrotransposons of humans and mice. Some of the restriction factors for retrotransposition, including the APOBECs, MOV10, RNASEL, SAMHD1, TREX1 ...
openaire   +2 more sources

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells

Stem Cells International, 2018
Retrotransposons comprise a significant fraction of mammalian genome with unclear functions. Increasing evidence shows that they are not just remnants of ancient retroviruses but play important roles in multiple biological processes. Retrotransposons are
Ying Yin, Liquan Zhou, Shuiqiao Yuan
doaj   +1 more source

Lost in translation : The biogenesis of non-LTR retrotransposon proteins

, 2013
This research was supported by UK Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust.“Young” APE-type non-LTR retrotransposons (non-LTRs) typically encode two open reading frames (ORFs 1 and 2).
Roulston, Claire, Odon, Valerie, Odon, V, de Felipe, Pablo, Sukhodub, Andriy, Ryan, MD, Ryan, Martin Denis, Roulston, C, Luke, GA, de Felipe, P, Sukhodub, A, Luke, Garry Alec   +11 more
core   +1 more source