Results 1 to 10 of about 17,779 (258)

ICTV Virus Taxonomy Profile: Retroviridae 2021 [PDF]

Journal of General Virology, 2021
Viruses in the family Retroviridae are found in a wide variety of vertebrate hosts. Enveloped virions are 80-100 nm in diameter with an inner core containing the viral genome and replicative enzymes. Core morphology is often characteristic for viruses within the same genus.
Jonas Blomberg, Dirk Lindemann, Jens Mayer   +2 more
exaly   +10 more sources

Relationships of gag-pol diversity between Ty3/Gypsy and Retroviridae LTR retroelements and the three kings hypothesis [PDF]

BMC Evolutionary Biology, 2008
Background The origin of vertebrate retroviruses (Retroviridae) is yet to be thoroughly investigated, but due to their similarity and identical gag-pol (and env) genome structure, it is accepted that they evolve from Ty3/Gypsy LTR retroelements the ...
Fares Mario A, Llorens Carlos, Moya Andres   +2 more
doaj   +8 more sources

Analysis of Tat protein characteristics in human immunodeficiency virus type 1 sub-subtype A6 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1)

Voprosy Virusologii, 2022
INTRODUCTION Tat protein is a major factor of HIV (human immunodeficiency virus) transcription regulation and has other activities. Tat is characterized by high variability, with some amino acid substitutions, including subtypespecific ones, being able ...
Anna Kuznetsova, Anastasia Murzakova, Aleksey Lebedev   +2 more
exaly   +4 more sources

Simple (Wrong) Models for Complex Trees: A Case from Retroviridae [PDF]

Molecular Biology and Evolution, 2001
Although the use of adequate models of evolution should improve the accuracy of phylogenetic inference (Leitner, Kumar, and Albert 1997; Sullivan and Swofford 1997; Cunningham, Zhu, and Hillis 1998), computer simulation studies have shown that under ...
David Posada, Keith A Crandall
exaly   +3 more sources

Antiviral activity of extracts of basidiomycetes and humic compounds substances against Human Immunodeficiency Virus (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus 1) and Herpes Simplex Virus (Herpesviridae: Simplexvirus: Human alphaherpesvirus 1)

Voprosy Virusologii, 2020
INTRODUCTION One of the most urgent problem of modern medicine is the fight against the disease caused by the Human Immunodeficiency Virus (HIV) - HIV infection.
N N Nosik, Tamara V Teplyakova, O A Lobach   +2 more
exaly   +4 more sources

Expression of integrins β1, α4 and cell adhesion molecule ICAM-1 in the presence of sodium deoxyribonucleate with ferrum complex (DNA-Na-Fe) by MT-4 cells transformed by human T-lymphotropic virus type 1 (Retroviridae: Orthoretrovirinae: Deltaretrovirus: Human T-lymphotropic virus type 1)

Voprosy virusologii, 2021
INTRODUCTION The important role of integrins (IG) in the initiation and development of cancer processes makes these structures convenient targets for the development of immunomodulatory therapeutic drugs that have an effect directly on these molecules ...
Lyudmila B. Kalnina, L М Selimova, E N Kaplina, Д Н Носик   +3 more
openalex   +3 more sources

Study of the specific toxic effects of the substance 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil, the original non-nucleoside inhibitor of human immunodeficiency virus type 1 (Retroviridae; Orthoretrovirinae; Lentivirus: Human immunodeficiency virus 1) reverse transcriptase

Voprosy virusologii, 2021
INTRODUCTION Combination antiretroviral therapy is currently the main component of treatment for human immunodeficiency virus (HIV) infected patients.
E. A. Gaidai, K. L. Kryshen, E. A. Jain, Д. В. Демченко, Dinara R. Kargopoltseva, A.E. Katelnikova, D. S. Gaidai, V. Yu. Balabanyan   +7 more
openalex   +3 more sources

Evaluation of anti-HIV-1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus type 1) activity of 6HP and 3TC in vitro using MT-4 cell line variants with different replicative activity

Voprosy virusologii
INTRODUCTION Chemotherapy of HIV infection remains the only means of treating the disease. The process of development new and improving previously developed drugs is therefore considered a priority.
Lyudmila B. Kalnina, L М Selimova, Д Н Носик   +2 more
openalex   +2 more sources

Variability of non-structural proteins of HIV-1 sub-subtype A6 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1, sub-subtype A6) variants circulating in different regions of the Russian Federation

Voprosy virusologii
INTRODUCTION HIV-1 non-structural proteins are promising targets for vaccine development and for creating approaches to personalized medicine. HIV-1 sub-subtype A6 has become the dominating strain in Russia.
Anastasiia Antonova, Aleksey Lebedev, Ekaterina Ozhmegova, Anastasia V. Shlykova, Ilya Lapovok, Anna Kuznetsovа   +5 more
openalex   +2 more sources

The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure [PDF]

Frontiers in Pharmacology, 2015
Oncogenes are the primary candidates for target-directed therapy, given that they are involved directly in the progression and resistance of tumors. However, the appearance of point mutations can hinder the treatment of patients with these new molecules,
Janaína Fernandes
openalex   +2 more sources