Results 11 to 20 of about 21,285 (183)
INTRODUCTION The important role of integrins (IG) in the initiation and development of cancer processes makes these structures convenient targets for the development of immunomodulatory therapeutic drugs that have an effect directly on these molecules ...
L. Kalnina +3 more
semanticscholar +2 more sources
INTRODUCTION Tat protein is a major factor of HIV (human immunodeficiency virus) transcription regulation and has other activities. Tat is characterized by high variability, with some amino acid substitutions, including subtypespecific ones, being able ...
A. Kuznetsova +9 more
semanticscholar +3 more sources
INTRODUCTION One of the most urgent problem of modern medicine is the fight against the disease caused by the Human Immunodeficiency Virus (HIV) - HIV infection.
D. N. Nosik +7 more
semanticscholar +2 more sources
INTRODUCTION Chemotherapy of HIV infection remains the only means of treating the disease. The process of development new and improving previously developed drugs is therefore considered a priority.
Lyudmila B. Kalnina +2 more
semanticscholar +3 more sources
INTRODUCTION The human immunodeficiency virus (HIV) Nef protein is one of the key factors determining the infectivity and replicative properties of HIV.
K. Gromov +5 more
semanticscholar +2 more sources
INTRODUCTION The persistence of immune dysfunction during therapy has serious consequences for the health of HIV-infected people. Therefore, an important direction is the search for drugs that can reduce the inflammatory potential of the immune system ...
D. N. Nosik +3 more
semanticscholar +3 more sources
INTRODUCTION HIV-1 non-structural proteins are promising targets for vaccine development and for creating approaches to personalized medicine. HIV-1 sub-subtype A6 has become the dominating strain in Russia.
A. Antonova +5 more
semanticscholar +3 more sources
The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure [PDF]
Oncogenes are the primary candidates for target-directed therapy, given that they are involved directly in the progression and resistance of tumors. However, the appearance of point mutations can hinder the treatment of patients with these new molecules,
Janaína Fernandes
semanticscholar +2 more sources

