Results 11 to 20 of about 11,204 (215)

Relationships of gag-pol diversity between Ty3/Gypsy and Retroviridae LTR retroelements and the three kings hypothesis [PDF]

BMC Evolutionary Biology, 2008
Background The origin of vertebrate retroviruses (Retroviridae) is yet to be thoroughly investigated, but due to their similarity and identical gag-pol (and env) genome structure, it is accepted that they evolve from Ty3/Gypsy LTR retroelements the ...
Fares Mario A, Llorens Carlos, Moya Andres   +2 more
doaj   +3 more sources

Expression of integrins β1, α4 and cell adhesion molecule ICAM-1 in the presence of sodium deoxyribonucleate with ferrum complex (DNA-Na-Fe) by MT-4 cells transformed by human T-lymphotropic virus type 1 (Retroviridae: Orthoretrovirinae: Deltaretrovirus: Human T-lymphotropic virus type 1)

Voprosy virusologii, 2021
INTRODUCTION The important role of integrins (IG) in the initiation and development of cancer processes makes these structures convenient targets for the development of immunomodulatory therapeutic drugs that have an effect directly on these molecules ...
Lyudmila B. Kalnina, L М Selimova, E N Kaplina, Д Н Носик   +3 more
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Study of the specific toxic effects of the substance 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil, the original non-nucleoside inhibitor of human immunodeficiency virus type 1 (Retroviridae; Orthoretrovirinae; Lentivirus: Human immunodeficiency virus 1) reverse transcriptase

Voprosy virusologii, 2021
INTRODUCTION Combination antiretroviral therapy is currently the main component of treatment for human immunodeficiency virus (HIV) infected patients.
E. A. Gaidai, K. L. Kryshen, E. A. Jain, Д. В. Демченко, Dinara R. Kargopoltseva, A.E. Katelnikova, D. S. Gaidai, V. Yu. Balabanyan   +7 more
openalex   +3 more sources

Variability of non-structural proteins of HIV-1 sub-subtype A6 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1, sub-subtype A6) variants circulating in different regions of the Russian Federation

Voprosy virusologii
INTRODUCTION HIV-1 non-structural proteins are promising targets for vaccine development and for creating approaches to personalized medicine. HIV-1 sub-subtype A6 has become the dominating strain in Russia.
Anastasiia Antonova, Aleksey Lebedev, Ekaterina Ozhmegova, Anastasia Murzakova, Ilya Lapovok, Anna Kuznetsovа   +5 more
openalex   +2 more sources

Evaluation of anti-HIV-1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus type 1) activity of 6HP and 3TC in vitro using MT-4 cell line variants with different replicative activity

Voprosy virusologii
INTRODUCTION Chemotherapy of HIV infection remains the only means of treating the disease. The process of development new and improving previously developed drugs is therefore considered a priority.
Lyudmila B. Kalnina, L М Selimova, Д Н Носик   +2 more
openalex   +2 more sources

The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure [PDF]

Frontiers in Pharmacology, 2015
Oncogenes are the primary candidates for target-directed therapy, given that they are involved directly in the progression and resistance of tumors. However, the appearance of point mutations can hinder the treatment of patients with these new molecules,
Janaína Fernandes
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The effect of sodium deoxyribonucleate with iron complex on the expression of surface markers of MT-4 cells infected with human immunodeficiency virus type 1 (HIV-1) (Retroviridae: <i>Primate lentivirus group</i>)

Voprosy virusologii
INTRODUCTION The persistence of immune dysfunction during therapy has serious consequences for the health of HIV-infected people. Therefore, an important direction is the search for drugs that can reduce the inflammatory potential of the immune system ...
Д Н Носик, Lyudmila B. Kalnina, L М Selimova, E N Kaplina   +3 more
openalex   +2 more sources

Genetic diversity of Vif protein in human immunodeficiency virus type 1 variants (Retroviridae: <i>Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1</i>) that circulated in the Moscow region in 2019–2020

Problems of virology
Introduction. The Vif protein counteracts cellular deaminases, APOBEC3, which prevent viral replication. Vif is used for development of therapeutic agents.
Anastasiia Antonova, Larisa A. Protasova, K. V. Kim, Iana M. Munchak, Ekaterina Ozhmegova, Elena Orlova-Morozova, A. Yu. Pronin, А. Г. Прилипов, Anna Kuznetsovа   +8 more
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Fecal Virome of Southeastern Maned Sloth (Bradypus crinitus) (Pilosa: Bradypodidae) [PDF]

Genetics and Molecular Biology
We report a viral metagenomic analysis of fecal samples from Bradypus crinitus (Pilosa: Bradypodidae), a recently described sloth species that occurs in the Atlantic Forest of Espírito Santo and Rio de Janeiro states, Southeast Brazil.
Amanda Coimbra, Mirela D’arc, Filipe Romero Rebello Moreira, Matheus Augusto Calvano Cosentino, Francine Bittencourt Schiffler, Thamiris dos Santos Miranda, Ricardo Mouta, Déa Luiza Girardi, Victor Wanderkoke, Gabriel Medeiros, Talitha Mayumi Francisco, Flávio Landim Soffiati, Suelen Sanches Ferreira, Carlos Ramon Ruiz-Miranda, Marcelo Alves Soares, André Felipe dos Santos   +15 more
doaj   +2 more sources

Analysis of HIV-1 (Human immunodeficiency virus-1, Lentivirus, Orthoretrovirinae, Retroviridae) Nef protein polymorphism of variants circulating in the former USSR countries

Voprosy virusologii, 2019
INTRODUCTION The human immunodeficiency virus (HIV) Nef protein is one of the key factors determining the infectivity and replicative properties of HIV.
K. B. Gromov, E. V. Kazennova, Dmitry Kireev, A. V. Murzakova, Alexey Lopatukhin, Bobkova Mr   +5 more
openalex   +3 more sources