Results 91 to 100 of about 165,526 (354)
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity
Advanced Science, Volume 12, Issue 28, July 24, 2025.This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang +13 more
wiley +1 more source
Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder
Advanced Science, EarlyView.The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang +13 more
wiley +1 more source
Retroviral RNA Dimerization: From Structure to Functions
Frontiers in Microbiology, 2018 The genome of the retroviruses is a dimer composed by two homologous copies of genomic RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA molecules to be non-covalently linked together through intermolecular base-pairing.
Noé Dubois +3 more
doaj +1 more source
The Epidemiology of Koala Retrovirus
Journal of Veterinary Epidemiology, 2011 A novel Gammaretrovirus, named Koala retrovirus (KoRV) was identified in koalas in 2000. Subsequent testing has shown that KoRV appears to be widespread throughout the wild koala population in Australia. KoRV is apparently unique in that it is the only known example of an exogenous retrovirus which is actively undergoing the process of endogenisation ...
Simmons, Greg +4 more
openaire +4 more sources
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
Insertional Oncogenesis by Non-Acute Retroviruses: Implications for Gene Therapy
Viruses, 2011 Retroviruses cause cancers in a variety of animals and humans. Research on retroviruses has provided important insights into mechanisms of oncogenesis in humans, including the discovery of viral oncogenes and cellular proto-oncogenes. The subject of this
Hung Fan, Chassidy Johnson
doaj +1 more source
Retrovirus Infection and Retinoid [PDF]
, 2011 Human T cell leukemia virus type I (HTLV-I) is a human retrovirus that is an etiologic agent of adult T cell leukemia/lymphoma (ATL/ATLL) ( Hinuma et al., 1981, Uchiyama et al., 1977). Adult ATL/ATLL is an aggressive lymphoid neoplasm associated with human T-cell leukemia virus type 1 (HTLV-1) (Hinuma et al, 1982). ATL, the first human disease found to
Jun-ichi Miyatake +5 more
openaire +3 more sources
Advanced Science, EarlyView.This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan +16 more
wiley +1 more source
Intracellular Defenses Against HIV, Viral Evasion and Novel Therapeutic Approaches
Journal of the Formosan Medical Association, 2011 Human immunodeficiency virus (HIV), the causative agent of AIDS, is a retrovirus. It is estimated that, while in the cell, it interacts with almost 10% of cellular proteins.
Robert A Lever, Andrew M L Lever
doaj +1 more source
Intramolecular integration within Moloney murine leukemia virus DNA [PDF]
, 1981 By screening a library of unintegrated, circular Moloney murine leukemia virus (M-MuLV) DNA cloned in lambda phage, we found that approximately 20% of the M-MuLV DNA inserts contained internal sequence deletions or inversions.
Baltimore, David +3 more
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