Results 41 to 50 of about 168,869 (309)

PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

Viruses, 2015
Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades.
Amanda R. Panfil, Jacob Al-Saleem, Cory M. Howard, Jessica M. Mates, Jesse J. Kwiek, Robert A. Baiocchi, Patrick L. Green   +6 more
doaj   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

High levels of anti‐Nef antibodies may prevent AIDS disease progression in vertically HIV‐1‐infected infants

Journal of the International AIDS Society, 2014
Introduction HIV‐1‐associated CD4+ T‐cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of
Guillermo Corró, Cintia Milena Crudeli, Carlos Alberto Rocco, Silvia Alejandra Marino, Luisa Sen   +4 more
doaj   +1 more source

The Expression of Tax and HBZ Genes in Serum-Derived Extracellular Vesicles From HTLV-1 Carriers Correlates to Proviral Load and Inflammatory Markers

Frontiers in Microbiology, 2022
Human T-lymphotropic virus 1 (HTLV-1) is the etiologic agent of adult cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Debora Glenda Lima de La-Roque, Elaine Vieira Santos, Evandra Strazza Rodrigues, Péricles Natan Mendes da Costa, Verônica Soares Brauer, Fausto Almeida, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima   +9 more
doaj   +1 more source

Complete genome sequences of two feline Leukemia virus subgroup B isolates with novel recombination sites [PDF]

, 2013
It is generally accepted that all primary isolates of feline leukemia virus (FeLV) contain a subgroup A virus (FeLV-A) that is essential for transmission.
Bae, Berry, Busch, Canfield, McDougall, Miyazawa, Niman, Roca, Sarma, Sheets, Stewart, Stewart, Wilson   +12 more
core   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models

Cells, 2019
Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues into immunocompetent mice. Since a PDX model retains the characteristics of the primary patient tumor including gene expression profiles and drug responses, it has
Seiji Okada, Kulthida Vaeteewoottacharn, Ryusho Kariya   +2 more
doaj   +1 more source

Retrovirus Restriction Factors [PDF]

Molecular Cell, 2004
A number of cellular genes have recently been identified that actively inhibit retrovirus replication and so protect cells from infection. The genes target many distinct steps in the viral life cycle: entry, viral DNA synthesis, intracellular movement of viral nucleic acids, and viral gene expression.
openaire   +2 more sources

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

GITR triggering has limited impact on HIV-specific CD8 T-cell function but enhances HIV transcription reactivation from latently infected CD4 T-cells

Scientific Reports
Glucocorticoid-Induced TNFR-related protein (GITR) is a costimulatory molecule involved in the proliferation and effector functions of CD8 + and CD4 + T-cells. Recently, it has gained attention as a novel target for HIV immunotherapy. However, reports on
Alejandro Czernikier, Lucia Baquero, Paula Benencio, Laura A. Osorio Ocampo, Jimena Salido, Ana Gun, María I. Figueroa, Natalia Laufer, Yanina Ghiglione, María F. Pascutti, Gabriela Turk   +10 more
doaj   +1 more source