Results 41 to 50 of about 161,769 (345)

Evaluation of Different Parameters of Humoral and Cellular Immune Responses in HIV Serodiscordant Heterosexual Couples: Humoral Response Potentially Implicated in Modulating Transmission Rates

EBioMedicine, 2017
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental.
María Julia Ruiz, Jimena Salido, Lorena Abusamra, Yanina Ghiglione, Cintia Cevallos, Gabriel Damilano, Ana María Rodriguez, César Trifone, Natalia Laufer, Luis D. Giavedoni, Omar Sued, Horacio Salomón, María Magdalena Gherardi, Gabriela Turk   +13 more
doaj   +1 more source

Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

Nature Communications, 2022
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al.
Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya, Shinsuke Nakajima, Masahito Tokunaga, Kisato Nosaka, Hiroyuki Hata, Atae Utsunomiya, Jun-ichi Fujisawa, Yorifumi Satou   +16 more
doaj   +1 more source

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

Biomolecules, 2023
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host antiviral immunity; however, 5–10% of carriers lose this balance and develop ATL.
Shingo Nakahata, Daniel Enriquez-Vera, M. Ishrat Jahan, Kenji Sugata, Yorifumi Satou   +4 more
doaj   +1 more source

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4+ T Cells

Molecular Therapy, 2016
The inherent risks associated with vector insertion in gene therapy need to be carefully assessed. We analyzed the genome-wide distributions of Sleeping Beauty (SB) and piggyBac (PB) transposon insertions as well as MLV retrovirus and HIV lentivirus ...
A. Gogol-Döring, Ismahen Ammar, Saumyashree Gupta, M. Bunse, Csaba Miskey, Wei Chen, W. Uckert, T. Schulz, Z. Izsvák, Z. Ivics   +9 more
semanticscholar   +1 more source

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Ehrhardt, Anja, Müther, Nadine, Noske, Nadja   +2 more
core   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes

Biology Open, 2022
Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk, Jet van der Spek, Tom van Duivenvoorde, Marieke S. ten Brink, Teunis B. H. Geijtenbeek, Coenraad P. Kuijl, Jeroen W. J. van Heijst, Louis S. Ates   +7 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection

Human Vaccines & Immunotherapeutics, 2018
HIV-specific T-cell responses play a key role in controlling HIV infection, and therapeutic vaccines for HIV that aim to improve viral control will likely need to improve on the T-cell responses induced by infection.
Paul Munson, Yi Liu, Debra Bratt, James T. Fuller, Xintao Hu, George N. Pavlakis, Barbara K. Felber, James I. Mullins, Deborah Heydenburg Fuller   +8 more
doaj   +1 more source