Results 51 to 60 of about 161,769 (345)

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Anderson, Andrew Wood, Asaoka, Bainbridge, Bartosch, Bartosch, Bartosch, Benjamin L. J. Webb, Berthoux, Besnier, Birke Bartosch, Bock, Greg J. Towers, Hanger, Hatziioannou, Hatziioannou, Hatziioannou, Jonsson, Kaiser, Keckesova, Keckesova, Le Tissier, Lieber, Lin, Martin, Martin, Mortuza, Naviaux, Negre, Neil, Newman, Niebert, Nisole, Oldmixon, Passerini, Patience, Patience, Perez-Caballero, Perron, Rambaut, Sakuma, Schaller, Si, Song, Stoye, Stoye, Stremlau, Stremlau, Stremlau, Takeuchi, Tarlinton, Torsten Schaller, Towers, Towers, Towers, Wilson, Wu, Yap, Yasuhiro Takeuchi, Ylinen, Ylinen, Zufferey   +61 more
core   +2 more sources

Molecular Genetics of Retrovirus Replication

Viruses, 2023
Despite the availability of effective anti-HIV drug therapy, according to UNAIDS estimates, 1 [...]
Judith G. Levin, Karin Musier-Forsyth, Alan Rein   +2 more
openaire   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

Viruses, 2015
Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades.
Amanda R. Panfil, Jacob Al-Saleem, Cory M. Howard, Jessica M. Mates, Jesse J. Kwiek, Robert A. Baiocchi, Patrick L. Green   +6 more
doaj   +1 more source

Inhibition of human endogenous retrovirus-K by antiretroviral drugs

Retrovirology, 2017
BackgroundHuman endogenous retroviruses (HERVs) are genomic sequences of retroviral origin which were believed to be integrated into germline chromosomes millions of years ago and account for nearly 8% of the human genome.
R. Tyagi, Wenxue Li, Danelvis Parades, M. Bianchet, A. Nath   +4 more
semanticscholar   +1 more source

Retrovirus Silencing by an Epigenetic TRIM [PDF]

Cell, 2007
Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the ...
James Ellis, Mojgan Rastegar, Akitsu Hotta   +2 more
openaire   +3 more sources

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

CML With Mutant ASXL1 Showed Decreased Sensitivity to TKI Treatment via Upregulation of the ALOX5-BLTR Signaling Pathway. [PDF]

Cancer Sci
We generated cell lines with inducible expression of ASXL1 mutations and found that ASXL1 mutation‐induced cell lines exhibited reduced ABL1 TKI sensitivity. We identified ALOX5 as one of the top upregulated genes under the expression of mutated ASXL1 and high expression of ALOX5 conferring TKI resistance. Inhibition of the ALOX5‐BLTR signaling pathway
Miyashita N, Onozawa M, Kasahara K, Matsukawa T, Onodera Y, Suzuki K, Takaku T, Teshima T, Kondo T.   +8 more
europepmc   +2 more sources

Childhood sexual experiences with an older partner among men who have sex with men in Buenos Aires, Argentina [PDF]

, 2013
This study sought to describe childhood sexual experiences with older partners (CSEOP) among men who have sex with men (MSM) in Buenos Aires, Argentina. MSM were recruited through respondent driven sampling. They responded to a computer administered self-
Balán, Iván C., Barreda, Victoria, Carballo Diéguez, A., Dolezal, Curtis, Mabragaña, Marina, Marone, Ruben, Pando, María de los Ángeles, Ávila, María Mercedes   +7 more
core   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source