Results 61 to 70 of about 161,769 (345)

High levels of anti‐Nef antibodies may prevent AIDS disease progression in vertically HIV‐1‐infected infants

Journal of the International AIDS Society, 2014
Introduction HIV‐1‐associated CD4+ T‐cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of
Guillermo Corró, Cintia Milena Crudeli, Carlos Alberto Rocco, Silvia Alejandra Marino, Luisa Sen   +4 more
doaj   +1 more source

Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat [PDF]

, 2009
TRIM5[alpha] mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved ...
Hosie, Margaret J., McEwan, William A., Schaller, Torsten, Towers, Greg J., Willett, Brian J., Ylinen, Laura M.   +5 more
core   +2 more sources

Organoid‐Like Neurovascular Spheroids Promote the Recovery of Hypoxic‐Ischemic Skin Flaps Through the Activation of Autophagy

Advanced Healthcare Materials, EarlyView.
Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie, Jingyi Ju, Zhenxing Wang, Jun Chen, Lin‐Ping Wu, Jiaming Sun   +5 more
wiley   +1 more source

Immune suppression of vaccine-induced CD8+ T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4+ T cells

Frontiers in Immunology, 2022
Retroviral envelope (Env) proteins have long been recognized to exhibit immunosuppressive properties, which affect the CD8+ T-cell response to an infection but also to immunization. Interestingly, we previously showed in the Friend murine leukemia virus
Philip Podschwadt, Anna Malyshkina, Sonja Windmann, Athanasios Papadamakis, Leonie Kerkmann, Dennis Lapuente, Matthias Tenbusch, Mengji Lu, Michael Schindler, Karl Sebastian Lang, Wiebke Hansen, Wibke Bayer   +11 more
doaj   +1 more source

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4

International Immunology, 2015
The envelope protein of an MS-associated retrovirus activates brain ...
A. Duperray, Delphin Barbe, G. Raguénez, B. Weksler, I. Romero, P. Couraud, H. Perron, P. Marche   +7 more
semanticscholar   +1 more source

Prevention of retrovirus-induced neurological disease by infection with a nonneuropathogenic retrovirus

Virology, 1995
Perinatal infection of susceptible mice with the neurotropic retrovirus CasBrE leads to a noninflammatory spongiform degeneration of the central nervous system with a long incubation period of up to 1 year. Virus replication in infected animals can be suppressed by administration of antiviral antibodies, cytotoxic T cells, or by AZT treatment, which ...
John L. Portis, Stefanie Czub, Frank J. McAtee, William P. Lynch, Markus Czub   +4 more
openaire   +3 more sources

Novel Endogenous Retrovirus in Rabbits Previously Reported as Human Retrovirus 5 [PDF]

Journal of Virology, 2002
ABSTRACT Human retrovirus 5 (HRV-5) represented a fragment of a novel retrovirus sequence identified in human RNA and DNA preparations. In this study, the genome of HRV-5 was cloned and sequenced and integration sites were analyzed. Using PCR and Southern hybridization, we showed that HRV-5 is not integrated into human DNA.
Cécile Voisset, Robin A. Weiss, Patrick J Venables, David J. Griffiths   +3 more
openaire   +3 more sources

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage

Viruses, 2018
Interferon inducible transmembrane proteins (IFITMs) are one of several IFN-stimulated genes (ISGs) that restrict entry of enveloped viruses, including flaviviruses, filoviruses and retroviruses.
Jingyou Yu, Shan-Lu Liu
doaj   +1 more source

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.

New England Journal of Medicine, 2014
BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully ...
S. Hacein-Bey-Abina, Sy Pai, H. Gaspar, M. Armant, C. C. Berry, S. Blanche, J. Bleesing, J. Blondeau, H. D. Boer, K. F. Buckland, L. Caccavelli, G. Cros, S. D. Oliveira, K. S. Fernández, D. Guo, C. E. Harris, G. Hopkins, L. E. Lehmann, A. Lim, W. B. London, J. C. V. D. Loo, N. Malani, F. Male, P. Malik, M. A. Marinovic, A.-M. McNicol, D. Moshous, B. Neven, M. Oleastro, C. Picard, J. Ritz, C. Rivat, A. Schambach, K. L. Shaw, E. A. Sherman, L. E. Silberstein, E. Six, F. Touzot, A. Tsytsykova, J. Xu-Bayford, C. Baum, F. D. Bushman, A. Fischer, D. B. Kohn, A. Filipovich, L. D. Notarangelo, M. Cavazzana, D. A. Williams, A. Thrasher   +48 more
semanticscholar   +1 more source