Results 61 to 70 of about 165,526 (354)

Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models

Cells, 2019
Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues into immunocompetent mice. Since a PDX model retains the characteristics of the primary patient tumor including gene expression profiles and drug responses, it has
Seiji Okada, Kulthida Vaeteewoottacharn, Ryusho Kariya   +2 more
doaj   +1 more source

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4

International Immunology, 2015
The envelope protein of an MS-associated retrovirus activates brain ...
A. Duperray, Delphin Barbe, G. Raguénez, B. Weksler, I. Romero, P. Couraud, H. Perron, P. Marche   +7 more
semanticscholar   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets [PDF]

, 2017
BACKGROUND: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans.
Akiyoshi, Bittmann, Claire Crossan, Clemenceau, Clemenceau, Cooper, Denner, Denner, Denner, Dieckhoff, Fishman, Gazda, Guo, Irgang, Kimsa, Korbutt, Linda Scobie, Matsumoto, Mazurek, Moon, Morozov, Mourad, Mueller, Nizar I. Mourad, Patience, Pierre Gianello, Pizzato, Schuurman, Scobie, Spizzo, Sypniewski, Tacke, Tucker, Victoria Cruikshank, Wynyard, Wynyard, Zhang   +36 more
core   +1 more source

Novel Endogenous Retrovirus in Rabbits Previously Reported as Human Retrovirus 5 [PDF]

Journal of Virology, 2002
ABSTRACT Human retrovirus 5 (HRV-5) represented a fragment of a novel retrovirus sequence identified in human RNA and DNA preparations. In this study, the genome of HRV-5 was cloned and sequenced and integration sites were analyzed. Using PCR and Southern hybridization, we showed that HRV-5 is not integrated into human DNA.
Cécile Voisset, Robin A. Weiss, Patrick J Venables, David J. Griffiths   +3 more
openaire   +3 more sources

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Emerging Role of LY6E in Virus–Host Interactions

Viruses, 2019
As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis.
Jingyou Yu, Shan-Lu Liu
doaj   +1 more source

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.

New England Journal of Medicine, 2014
BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully ...
S. Hacein-Bey-Abina, Sy Pai, H. Gaspar, M. Armant, C. C. Berry, S. Blanche, J. Bleesing, J. Blondeau, H. D. Boer, K. F. Buckland, L. Caccavelli, G. Cros, S. D. Oliveira, K. S. Fernández, D. Guo, C. E. Harris, G. Hopkins, L. E. Lehmann, A. Lim, W. B. London, J. C. V. D. Loo, N. Malani, F. Male, P. Malik, M. A. Marinovic, A.-M. McNicol, D. Moshous, B. Neven, M. Oleastro, C. Picard, J. Ritz, C. Rivat, A. Schambach, K. L. Shaw, E. A. Sherman, L. E. Silberstein, E. Six, F. Touzot, A. Tsytsykova, J. Xu-Bayford, C. Baum, F. D. Bushman, A. Fischer, D. B. Kohn, A. Filipovich, L. D. Notarangelo, M. Cavazzana, D. A. Williams, A. Thrasher   +48 more
semanticscholar   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP

Retrovirology, 2019
Background Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis.
Paola Miyazato, Misaki Matsuo, Benjy J. Y. Tan, Michiyo Tokunaga, Hiroo Katsuya, Saiful Islam, Jumpei Ito, Yasuhiro Murakawa, Yorifumi Satou   +8 more
doaj   +1 more source