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Retroviruses

Science, 1983
First brought to scientific attention as infectious cancer-causing agents nearly 80 years ago, retroviruses are popular in contemporary biology for many reasons. (i) The virus life cycle includes several events—in particular, reverse transcription of the viral RNA genome into DNA, orderly integration of viral DNA into host chromosomes, and utilization ...
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Retroviruses and Transposons: Wandering retroviruses?

Current Biology, 1994
Recent studies of genetically unstable strains of Drosophila suggest that retroviruses are not confined to vertebrates and indicate how they might be derived from transposable elements.
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Avian Retroviruses

Veterinary Clinics of North America: Food Animal Practice, 1997
Avian leukosis virus (ALV) and reticuloendotheliosis virus (REV) are the most common naturally occurring avian retroviruses associated with neoplastic disease conditions in domesticated poultry. Avian leukosis virus infects primarily chickens, whereas REV infects chickens, turkeys, and other avian species.
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Retroviruses and evolution

Cell Biophysics, 1986
A wide variety of different genetic elements and DNA sequences have used reverse transcription in their replication or transposition. Some of these elements may be evolutionarily related and show a continued evolution to autonomy from the cell genome. The evolution of a cancer reflects a similar drive for autonomy from the organism.
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Activation of human endogenous retroviruses and its physiological consequences

Nature reviews. Molecular cell biology, 2023
Nicholas Dopkins, Douglas F. Nixon
semanticscholar   +1 more source

Human endogenous retroviruses role in cancer cell stemness.

Seminars in Cancer Biology, 2018
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the critical issues of oncological diseases. In this scenario, increasing scientific evidences demonstrate that the activation of human endogenous retroviruses (HERVs ...
C. Matteucci   +3 more
semanticscholar   +1 more source

Manufacturing of Retroviruses

2011
Retrovirus vectors derived from moloney murine leukemia virus (MoMLV) were the first class of viral vectors developed for gene therapy. They have been extensively used in clinical trials, particularly in ex vivo transduction of hematopoietic stem cells.
Pedro E, Cruz   +6 more
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Retroviruses and Cancer

Clinical Infectious Diseases, 1982
Retroviruses are RNA viruses that reverse-transcribe their RNA into proviral DNA. These viruses are associated with a wide variety of cancers in chickens mice, cats, and monkeys. Some retroviruses cause a specific type of cancer soon after infection in a high proportion of animals, whereas others cause various cancers late after infection in a lower ...
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Packaging shRNA Retroviruses

Cold Spring Harbor Protocols, 2013
To silence a mammalian gene by RNAi using an encoded trigger, a short-hairpin RNA (shRNA) is integrated into the host cell genome as a stable transgene. Target cells are infected with viral plasmid containing shRNA inserted into the vector backbone. Before infection, the plasmid is transfected into a packaging cell line, which provides the trans-acting
Kenneth, Chang   +3 more
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