Osteoarthritis: Mechanisms and Therapeutic Advances
A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu+3 more
wiley +1 more source
Correction: Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy. [PDF]
Wang F+16 more
europepmc +1 more source
Potential Retroviruses in Plants: Tat1 Is Related to a Group of Arabidopsis thaliana Ty3/gypsy Retrotransposons That Encode Envelope-Like Proteins [PDF]
David A. Wright, Daniel F. Voytas
openalex +1 more source
Genomic imprinting at a porcine ZNF locus via a canonical imprinting mechanism
Abstract Genomic imprinting causes parent‐of‐origin dependent gene expression, primarily driven by a subset of germline differentially methylated regions that function as imprinting control regions at promoter‐associated CpG islands. While these mechanisms have been investigated in depth in mice and humans, our understanding of the molecular basis of ...
Jinsoo Ahn+5 more
wiley +1 more source
Microbiome-Immune Interaction in Pulmonary Arterial Hypertension: What Have We Missed? [PDF]
Zhou X+5 more
europepmc +1 more source
Abstract Introduction Randomized controlled trial evidence suggests that long‐acting injectable (LA‐I) cabotegravir and rilpivirine (CAB+RPV) has similar virological failure (VF) rates to daily oral therapy, but clinical practice evidence is lacking. Integrase inhibitor (INI) resistance may limit future therapy.
Kyle Ring+4 more
wiley +1 more source
Immune and vascular modulation by HERVs: the role of <i>CXCR1</i> and <i>IL18RAP</i> in dengue severity progression. [PDF]
Ferreira CS+8 more
europepmc +1 more source
Molecular Structure of a Gypsy Element of Drosophila Subobscura (Gypsyds) Constituting a Degenerate Form of Insect Retroviruses [PDF]
T. M. Alberola, Rosa de Llanos
openalex +1 more source
Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari+7 more
wiley +1 more source