Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model. [PDF]
Biomol Ther (Seoul), 2022 Lee SB, Yang HO.
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Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina. [PDF]
PLoS ONE, 2011 The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors.
Nissa J Mollema +7 more
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The Role of REV-ERB Receptors in Cancer Pathogenesis. [PDF]
Int J Mol Sci, 2023 REV-ERB receptors are members of the nuclear receptor superfamily of proteins, which act as both intracellular receptors and transcription factors, therefore modulating the expression of target genes. REV-ERBs act as transcription repressors because of their unique structure.
Gomatou G +5 more
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Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells [PDF]
ASN Neuro, 2019 Glioblastoma multiforme is the most aggressive brain tumor, and human T98G cells constitute a useful glioblastoma multiforme model to evaluate the chemotherapeutic agents.
Paula M. Wagner +2 more
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Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. [PDF]
Circulation, 2022 Background: The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases, but it is unknown whether cardiac molecular clock dysfunction is associated ...
Song S +25 more
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REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009. [PDF]
Biochem Pharmacol, 2018 Amador A +3 more
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REV-ERB Agonist SR9009 Regulates the Proliferation and Neurite Outgrowth/Suppression of Cultured Rat Adult Hippocampal Neural Stem/Progenitor Cells in a Concentration-Dependent Manner. [PDF]
Cell Mol Neurobiol, 2022 Shimozaki K.
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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β [PDF]
Nature, 2012 The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK-BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accessory feedback loop that contributes to clock function, their precise roles and importance remain unresolved.
Han Cho +14 more
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Rev-erbs: Integrating Metabolism Around the Clock [PDF]
, 2016 Mammalian circadian and metabolic physiologies are intertwined, and the nuclear Rev-erbα is a key transcriptional link between them. Rev-erbα, and the highly related Rev-erbβ, are potent transcriptional repressors that are required for the function of the core mammalian molecular clock.
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SR8278 inhibits cell proliferation independent of REV-ERB [PDF]
Abstract Background The small molecule SR8278 was initially identified as an antagonist of the REV-ERB (reverse c-ERBAa) nuclear receptor proteins, which play an important role in metabolism and circadian rhythms. Though SR8278 has been shown to have beneficial physiological effects in a variety of preclinical disease contexts, its impact on ...
Ushaswini Atluri +2 more
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