Results 41 to 50 of about 7,238 (191)
Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis. [PDF]
Int J Mol Sci, 2022 Circadian rhythms significantly affect metabolism, and their disruption leads to cardiometabolic diseases and fibrosis. The clock repressor Rev-Erb is mainly expressed in the liver, heart, lung, adipose tissue, skeletal muscles, and brain, recognized as a master regulator of metabolism, mitochondrial biogenesis, inflammatory response, and fibrosis ...
Raza GS, Sodum N, Kaya Y, Herzig KH.
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Rev-erb-α: an integrator of circadian rhythms and metabolism
Journal of Applied Physiology, 2009 The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are generated by an internal clock system, which synchronizes these daily variations to the day/night alternance. In addition, circadian oscillations
Hélène Duez, Bart Staels
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Rev-erb regulation of cholesterologenesis. [PDF]
Biochem Pharmacol, 2017 REV-ERBα and REV-ERBβ are heme regulated nuclear receptors that are known to regulate metabolic pathways. We previously demonstrated that treatment of mice with synthetic REV-ERB agonists suppressed plasma cholesterol levels and the hepatic levels of the rate limiting enzyme in cholesterol biosynthesis (3-hydroxy-3-methylglutaryl-CoA reductase).
Sitaula S, Zhang J, Ruiz F, Burris TP.
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Regulating the Clock: REV-ERB Agonists as Promising Therapeutic Agents. [PDF]
GEN Biotechnol, 2023 Prasad C, Sundar IK.
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Rev-erb Agonist Inhibits Chikungunya and O'nyong'nyong Virus Replication. [PDF]
Open Forum Infect Dis, 2018 Abstract Chikungunya virus (CHIKV), an alphavirus spread by Aedes spp. mosquitos, causes severe inflammation and joint pain, progressing to a chronic arthralgic state in a subset of patients. Due to recent global epidemics of CHIKV and the potential for related viruses to cause outbreaks, multiple approaches to combat these pathogens are
Hwang J, Jiang A, Fikrig E.
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Biology, 2021 Long-term continuous light exposure (CL) and western diet (WD) effects on Adropin expression, RORα, and Rev-erb-α nuclear receptors and energy homeostasis were studied in rats.
Mahmoud Mustafa Ali Abulmeaty +8 more
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Suppression of atherosclerosis by synthetic REV-ERB agonist. [PDF]
Biochem Biophys Res Commun, 2015 The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis.
Sitaula S +4 more
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Circadian control of hepatitis B virus replication
Nature Communications, 2021 The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al.
Xiaodong Zhuang +21 more
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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists [PDF]
Nature, 2012 Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-ERB-β have an integral role in regulating the expression of core clock proteins driving rhythms in activity and metabolism.
Laura A. Solt +14 more
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Rev-erb agonist SR9009 inhibits the proliferation of human colon cancer cell line HCT116 through reducing autophagy [PDF]
Jichu yixue yu linchuang, 2020 Objective To investigate the effect of hemeregulated nuclear receptor(Rev-erb) agonist SR9009 on the proliferation and potential mechanism of human colon cancer cell line HCT116.
SHI Guang, NING Na, HOU Xiao-hong, SUN Cong, YUAN Yuan, WANG Li, WANG Xiao-hui
doaj