Results 61 to 70 of about 7,238 (191)

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Frontiers in Cell and Developmental Biology, 2021
Polycystic ovary syndrome (PCOS) is an endocrinopathy with complex pathophysiology that is a common cause of anovulatory infertility in women. Although the disruption of circadian rhythms is indicated in PCOS, the role of the clock in the etiology of ...
Lihua Sun, Hui Tian, Songguo Xue, Hongjuan Ye, Xue Xue, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Shaorong Gao   +9 more
doaj   +1 more source

Adropin: An endocrine link between the biological clock and cholesterol homeostasis [PDF]

, 2014
This article explores two translation models circling around the key issue “equivalence” in translation studies. They are the Jerome Model and the Horace Model. They differentiate from each other in the aspects of the translating priorities and purposes,
Rao, D. C, et al,
core   +3 more sources

Determination of genetic changes of Rev-erb beta and Rev-erb alpha genes in Type 2 diabetes mellitus by next-generation sequencing

Gene, 2020
The nuclear receptors Rev-erb alpha and Rev-erb beta are transcription factors that regulate the function of genes in glucose and lipid metabolism, and they also form a link between circadian rhythm and metabolism. We evaluated the variations in Rev-erb alpha and Rev-erb beta genes together with biochemical parameters as risk factors in type 2 diabetic
Bengu Tokat, Deniz Kanca-Demirci, Nurdan Gul, Ilhan Satman, Oguz Ozturk, Aclan Ozder, Ozlem Kucukhuseyin, Hulya Yilmaz-Aydogan   +7 more
openaire   +3 more sources

Expression of AFP and Rev-Erb A/Rev-Erb B and N-CoR in fetal rat liver, liver injury and liver regeneration [PDF]

Comparative Hepatology, 2006
AbstractBackgroundAlpha-fetoprotein (AFP) expression can resume in the adult liver under pathophysiological conditions. Orphan nuclear receptors were supposed to regulate AFP gene expression,in vitro. We were interested to study the expression of AFP and orphan nuclear receptors,in vivo.ResultsThe expression of AFP gene and orphan nuclear receptors in ...
Meier, Volker, Tron, Kyrylo, Batusic, Danko, Elmaouhoub, Abderrahim, Ramadori, Giuliano   +4 more
openaire   +3 more sources

Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]

, 2017
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core   +2 more sources

Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands [PDF]

Endocrinology, 2010
The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbα expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to expression of adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for REV-ERB, and binding of heme is required for the ...
Naresh, Kumar, Laura A, Solt, Yongjun, Wang, Pamela M, Rogers, Gargi, Bhattacharyya, Theodore M, Kamenecka, Keith R, Stayrook, Christine, Crumbley, Z Elizabeth, Floyd, Jeffrey M, Gimble, Patrick R, Griffin, Thomas P, Burris   +11 more
openaire   +2 more sources

Social isolation increases metabolic rate in the transition of light- to dark- phase and advances Rev-erb-α expression in brown adipose tissue to regulate daily rhythm of core body temperature in mice

Journal of Photochemistry and Photobiology, 2023
Mammals use social thermoregulation to maintain the core body temperature (Tc) at a lower energy cost. Brown adipose tissue (BAT) plays a crucial role in thermoregulation.
Paola Fernandes, Hellen Nunes, Tamires Amorim Marinho, Pietra Souza Barsanele, Maria Nathália Moraes, Maristela de Oliveira Poletini   +5 more
doaj   +1 more source

Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]

, 2017
The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana, Leinweber, Brinja, Oster, Henrik, Tsang, Anthony H.   +3 more
core   +2 more sources

SR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRα/FOXM1 pathway independently of REV-ERBs

Cell Death and Disease, 2022
Perturbations of the circadian clock are linked to multiple diseases, including cancers. Pharmacological activation of REV-ERB nuclear receptors, the core components of the circadian clock, has antitumor effects on various malignancies, while the impact ...
Hang Xu, Jiapeng Zhang, Xiaonan Zheng, Ping Tan, Xingyu Xiong, Xianyanling Yi, Yang Yang, Yan Wang, Dazhou Liao, Hong Li, Qiang Wei, Jianzhong Ai, Lu Yang   +12 more
doaj   +1 more source

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]

, 2013
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina, Baeza-Raja, Bernat, Eckel-Mahan, Kristin, Ptácek, Louis J, Sassone-Corsi, Paolo, Tsigelny, Igor F, Vagena, Eirini, Zhang, Luoying   +7 more
core   +2 more sources