Results 81 to 90 of about 7,238 (191)

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription [PDF]

Nature, 2013
Rev-Erb-α and Rev-Erb-β are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting nuclear receptor co-repressor (NCoR)-HDAC3 complexes to Rev-Erb response elements in enhancers and promoters of target genes,
Lam, Michael T.Y., Cho, Han, Lesch, Hanna P., Gosselin, David, Heinz, Sven, Tanaka-Oishi, Yumiko, Benner, Christopher, Kaikkonen, Minna U., Kim, Aneeza S., Kosaka, Mika, Lee, Cindy Y., Watt, Andy, Grossman, Tamar R., Rosenfeld, Michael G., Evans, Ronald M., Glass, Christopher K.   +15 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, Volume 600, Issue 6, Page 847-861, March 2026.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]

, 2018
BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara, Del Fiore, Paolo, Mocellin, Simone, Rajendran, Senthilkumar, Rossi, Carlo Riccardo, Spiro, Giovanna, Tropea, Saveria   +6 more
core   +2 more sources

Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB [PDF]

Cell Metabolism, 2015
The molecular clock is a master controller of circadian cellular processes that affect growth, metabolic homeostasis, and behavior. A report in Science by Zhang et al. (2015) redefines our understanding of how Rev-erba acts as an internal feedback inhibitor that modulates activity of the core clock while simultaneously regulating tissue-specific ...
Butler, Andrew A., Burris, Thomas P.
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, Volume 600, Issue 6, Page 765-792, March 2026.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, Volume 13, Issue 18, 27 March 2026.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Daily rhythms in expression of genes of hepatic lipid metabolism in Atlantic salmon (Salmo salar L.).

PLoS ONE, 2014
In mammals, several genes involved in liver lipid and cholesterol homeostasis are rhythmically expressed with expression shown to be regulated by clock genes via Rev-erb 1α.
Mónica B Betancor, Elsbeth McStay, Matteo Minghetti, Hervé Migaud, Douglas R Tocher, Andrew Davie   +5 more
doaj   +1 more source

Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator [PDF]

, 2016
Mammals evolved an endogenous timing system to coordinate their physiology and behaviour to the 24h period of the solar day. While it is well accepted that circadian rhythms are generated by intracellular transcriptional feedback loops, it is still ...
Herzel, Hanspeter, Korencic, Anja, Kramer, Achim, Pett, J. Patrick, Wesener, Felix   +4 more
core   +5 more sources

12-h clock regulation of genetic information flow by XBP1s [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer,
Abdurehman, Leymaan, Ballance, Heather, Chen, Xi, Dacso, Clifford C., Gonzalez, Naomi, Kim, Sam-Moon, Levy, Oren, Liu, Silvia, McClung, Colleen A., Meng, Huan, O’Malley, Bert W., Pan, Yinghong, Schnytzer, Yisrael, York, Brian, Zhu, Bokai   +14 more
core   +1 more source

REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology [PDF]

Cell Research, 2012
A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior, but when this synchronization is disturbed, chronic diseases such as metabolic syndrome and depression may develop. Three new studies show that nuclear receptors of the Rev-Erb family impact the circadian oscillator and its metabolic output and this can ...
Ripperger, Jürgen A., Albrecht, Urs
openaire   +3 more sources