Results 11 to 20 of about 5,958,314 (335)

Reversal learning in Drosophila larvae [PDF]

Learning & Memory, 2019
Adjusting behavior to changed environmental contingencies is critical for survival, and reversal learning provides an experimental handle on such cognitive flexibility. Here, we investigate reversal learning in larval Drosophila.
Nino Mancini, Sia Hranova, Julia Weber, Aliće Weiglein, M. Schleyer, Denise Weber, Andreas S. Thum, B. Gerber   +7 more
semanticscholar   +5 more sources

Dorsolateral striatum engagement during reversal learning [PDF]

Learning & Memory, 2020
Most experimental preparations demonstrate a role for dorsolateral striatum (DLS) in stimulus-response, but not outcome-based, learning. Here, we assessed DLS involvement in a touchscreen-based reversal task requiring mice to update choice following a ...
H. Bergstrom, Abby G. Lieberman, C. Graybeal, Anna M Lipkin, A. Holmes   +4 more
semanticscholar   +3 more sources

Impaired Reversal Learning in APPPS1-21 Mice in the Touchscreen Visual Discrimination Task

Frontiers in Behavioral Neuroscience, 2019
Preclinical-clinical translation of cognitive functions has been difficult in Alzheimer’s disease (AD) research but is crucial to the (predictive) validity of AD animal models.
Lore Van den Broeck, Pierre Hansquine, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge   +3 more
doaj   +2 more sources

Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits

eLife, 2018
The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed.
Marios C Panayi, Simon Killcross
doaj   +2 more sources

Dissociable effects of 5-HT2C receptor antagonism and genetic inactivation on perseverance and learned non-reward in an egocentric spatial reversal task [PDF]

, 2013
Cognitive flexibility can be assessed in reversal learning tests, which are sensitive to modulation of 5-HT2C receptor (5-HT2CR) function. Successful performance in these tests depends on at least two dissociable cognitive mechanisms which may separately
A Bari, A Castensson, A Gobert, A Slabosz, AC Roberts, AMJ Young, B Jones, CM Butter, D Cook, D Masaki, D Tait, DM Barch, DR Weinberger, E Shadach, Elizabeth M. Somerville, EP Pälvimäki, G Di Giovanni, GA Kennett, HF Clarke, HF Clarke, IM Wieselgren, J Sandson, JA Mitchell, KJ Jeffery, L Abdallah, LH Tecott, LH Tecott, M Potegal, M Sodhi, MDS Lapiz-Bluhm, ME Ragozzino, MG Packard, MG Packard, MJ Millan, P Powchik, PD Harvey, Peter G. Clifton, PG Clifton, PL Clatworthy, PM Baker, R Elliott, R Swainson, RC Arora, RE Lubow, S Davis, S Nilsson, SB Floresco, SB Floresco, SB Park, Simon R. O. Nilsson, Stefan Strack, T Sharp, TV Bliss, V Boulougouris, V Boulougouris, V Di Matteo, V Di Matteo, VC Leeson, YG Ni   +58 more
core   +22 more sources

Trait anxiety is associated with hidden state inference during aversive reversal learning

bioRxiv, 2023
Updating beliefs in changing environments can be driven by gradually adapting expectations or by relying on inferred hidden states (i.e., contexts), and changes therein. Previous work suggests that increased reliance on context could underly fear relapse
Ondrej Zika, K. Wiech, A. Reinecke, Michael Browning, Nicolas W. Schuck   +4 more
semanticscholar   +1 more source

Reversal of a Spatial Discrimination Task in the Common Octopus (Octopus vulgaris)

Frontiers in Behavioral Neuroscience, 2021
Reversal learning requires an animal to learn to discriminate between two stimuli but reverse its responses to these stimuli every time it has reached a learning criterion.
Alexander Bublitz, Guido Dehnhardt, Frederike D. Hanke   +2 more
doaj   +1 more source

Sufficient reliability of the behavioral and computational readouts of a probabilistic reversal learning task

Behavior Research Methods, 2021
Task-based measures that capture neurocognitive processes can help bridge the gap between brain and behavior. To transfer tasks to clinical application, reliability is a crucial benchmark because it imposes an upper bound to potential correlations with ...
M. Waltmann, F. Schlagenhauf, L. Deserno
semanticscholar   +1 more source

Alcohol Consumption during Adulthood Does Not Impair Later Go/No-Go Reversal Learning in Male Rats

NeuroSci, 2021
Reversal learning tasks are used to model flexible decision-making in laboratory animals, and exposure to drugs of abuse can cause long-term impairments in reversal learning. However, the long-term effects of alcohol on reversal learning have varied.
Charles L. Pickens, Mark Gallo, Hayley Fisher, Alisa Pajser, Madelyn H. Ray   +4 more
doaj   +1 more source

Effects of transcutaneous auricular vagus nerve stimulation on reversal learning, tonic pupil size, salivary alpha-amylase, and cortisol.

Psychophysiology, 2021
This study investigated whether transcutaneous auricular vagus nerve stimulation (taVNS) enhances reversal learning and augments noradrenergic biomarkers (i.e., pupil size, cortisol, and salivary alpha-amylase [sAA]). We also explored the effect of taVNS
Martina D’Agostini, A. Burger, Mathijs Franssen, Nathalie Claes, M. Weymar, A. von Leupoldt, I. Van Diest   +6 more
semanticscholar   +1 more source