Central medial and paraventricular thalamic afferents to the orbitofrontal cortex have differential effects on reversal learning [PDF]
Neurobiology of StressCognitive impairments are prominent in stress-related psychiatric disorders, such as depression and PTSD. While current therapies may improve mood symptoms, many patients experience persistent deficits in cognitive flexibility.
Kathleen M. Tuite +3 more
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Reversal learning is influenced by cognitive flexibility and develops throughout early adolescence [PDF]
npj Science of LearningLearning behavioural responses and adapting them based on feedback is crucial from a young age, continuing to develop into young adulthood. This study examines the development trajectory and contributing factors from childhood to adulthood using a ...
Christoph Bamberg +2 more
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Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks [PDF]
eLifeIn probabilistic reversal learning, the choice option yielding reward with higher probability switches at a random trial. To perform optimally in this task, one has to accumulate evidence across trials to infer the probability that a reversal has ...
Christopher M Kim +2 more
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Cell Reports, 2016 Neural circuits involving midbrain dopaminergic (DA) neurons regulate reward and goal-directed behaviors. Although local GABAergic input is known to modulate DA circuits, the mechanism that controls excitatory/inhibitory synaptic balance in DA neurons ...
Sarah X. Luo +8 more
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Prefrontal serotonin depletion delays reversal learning and increases theta synchronization of the infralimbic-prelimbic-orbitofrontal prefrontal cortex circuit [PDF]
Frontiers in PharmacologyIntroductionPrefrontal serotonin plays a role in the expression of flexible behavior during reversal learning tasks as its depletion delays reversal learning.
Yoana Estrada-Reyes +4 more
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Dopamine release in human associative striatum during reversal learning [PDF]
Nat CommunThe dopaminergic system is firmly implicated in reversal learning but human measurements of dopamine release as a correlate of reversal learning success are lacking.
F. Grill +6 more
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Inhibition of midbrain cholinergic neurons impairs decision-making strategies during reversal learning [PDF]
Frontiers in Molecular NeuroscienceIntroductionThe pedunculopontine nucleus (PPN) plays a role in coordinating complex behaviors and adapting to changing environmental conditions. The specific role of cholinergic neurons in PPN function is not well understood, but their ascending ...
Yuwoong Kim +3 more
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Biological Psychiatry, 2021 BACKGROUND Patients with obsessive-compulsive disorder (OCD) display disrupted performance and abnormal lateral orbitofrontal cortex (LOFC) activity during reversal learning tasks. However, it is unknown whether compulsions and reversal learning deficits
Elizabeth E. Manning +4 more
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Pharmaceuticals, 2021 Cognitive flexibility refers to the ability to modify learned behavior in response to changes in the environment. In laboratory rodents, cognitive flexibility can be assessed in reversal learning, i.e., the change of contingencies, for example in T-maze ...
Ahmet Oguzhan Bicakci +4 more
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Basic reversal-learning capacity in flies suggests rudiments of complex cognition. [PDF]
PLoS ONE, 2017 The most basic models of learning are reinforcement learning models (for instance, classical and operant conditioning) that posit a constant learning rate; however many animals change their learning rates with experience.
Brad R Foley +2 more
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