Results 91 to 100 of about 75,561 (275)

Effect of moderate alcohol consumption on parameters of reverse cholesterol transport in postmenopausal women

, 2004
Background: Alcohol consumption is associated with increased high-density lipoprotein (HDL) cholesterol levels. One of the main antiatherogenic functions of HDL is reverse cholesterol transport.
Sierksma, A, van der Gaag, MS, Tol, Aad, Grobbee, D.E., Scheek, L.M., Vermunt, SHF, Hendriks, HFJ, Gaag, M.S., Gaag, M.S. van der, Sierksma, A., van Tol, A., Hendriks, H.F., Hendriks, H.F.J., Tol, A. van, Scheek, LM (Leo), Vermunt, S.H., Grobbee, DE (Diederick), Lankhuizen, Inge, Vermunt, S.H.F., Lankhuizen, I.M.   +19 more
core   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Regulation of human CETP gene expression

Journal of Lipid Research, 2003
Cholesteryl ester transfer protein (CETP) is a key factor in plasma reverse cholesterol transport and is implicated in the pathophysiology of atherogenic dyslipidemia.
Wilfried Le Goff, Maryse Guerin, Laure Petit, M.John Chapman, Joe¨lle Thillet   +4 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Role of LCAT in HDL remodeling: investigation of LCAT deficiency states

Journal of Lipid Research, 2007
To better understand the role of LCAT in HDL metabolism, we compared HDL subpopulations in subjects with homozygous (n = 11) and heterozygous (n = 11) LCAT deficiency with controls (n = 22). Distribution and concentrations of apolipoprotein A-I (apoA-I)-,
Bela F. Asztalos, Ernst J. Schaefer, Katalin V. Horvath, Shizuya Yamashita, Michael Miller, Guido Franceschini, Laura Calabresi   +6 more
doaj   +1 more source

Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia

, 2011
Objective— Low high-density lipoprotein (HDL) cholesterol levels are frequently observed in familial hypercholesterolemia (FH) and might be associated with functional alterations of HDL particles that may influence their ...
Zélie Julia, Natalie Fournier, Chapman, M. John, Le Goff, Wilfried, Lesnik, Philippe, Julia, Zélie, Emilie Duchene, Carrie, Alain, Alexina Orsoni, M. John Chapman, Bruckert, Eric, Natacha Bellanger, Alain Carrie, Pirault, John, Fournier, Natalie, Orsoni, Alexina, Bonnefont-Rousselot, Dominique, Dominique Bonnefont-Rousselot, Wilfried Le Goff, Saint-Charles, Flora, Guerin, Maryse, Flora Saint-Charles, Duchene, Emilie, Eric Frisdal, Philippe Lesnik, Frisdal, Eric, Maryse Guerin, John Pirault, Bellanger, Natacha, Eric Bruckert   +29 more
core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Cholesterol metabolism: physiological regulation and diseases

MedComm
Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but is also the fundamental cause of other ailments.
Jiarui Guo, Silong Chen, Ying Zhang, Jinxia Liu, Luyang Jiang, Lidan Hu, Ke Yao, Yibo Yu, Xiangjun Chen   +8 more
doaj   +1 more source

The High Density Lipoprotein Cholesterol Hypothesis Revisited

Indonesian Biomedical Journal, 2018
BACKGROUND: The strong inverse association of plasma levels of high-density lipoprotein cholesterol (HDL-C) with coronary heart disease (CHD) found in human epidemiological studies led to the development of the ‘HDL-C hypothesis’, which posits that ...
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya   +2 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source